2024年10月7日,浙江大学杨益大、钱鹏旭及金希共同通讯在Nature Communications在线发表题为“Single-cell RNA sequencing reveals the pro-inflammatory roles of liver-resident Th1-like cells in primary biliary cholangitis”的研究论文,...
近日,美国哈佛医学院和布里格姆妇产医院联合项目——恒大免疫疾病中心的Vijay K. Kuchroo教授及其合作者在Immunity杂志上发表了题为Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling的文章。该文...
参考文献 Jin, Ciliang et al. “Single-cell RNA sequencing reveals the pro-inflammatory roles of liver-resident Th1-like cells in primary biliary cholangitis.” Nature communications vol. 15,1 8690. 7 Oct. 2024.
To determine whether Plasmodium-specific Th1- and Tfh-like effector cells generate memory populations that contribute to protection, we developed transgenic parasites that enable high-resolution study of anti-malarial memory CD4 Tcells in experimental models. We found that populations of both Th1- and...
Treg cells coexpress genes that are also expressed by the effector cells they control.Depending on the type of response they control,Treg cells are classified as Th1-like(controlling type I responses),Th2-like(controlling type II responses),or Th17-like(controlling type III responses).Many ...
1.Wang H, Fang K, Yan W, Chang X. T-Cell Immune Imbalance in Rheumatoid Arthritis Is Associated with Alterations in NK Cells and NK-Like T Cells Expressing CD38. J Innate Immun. 2022;14(2):148-166. 2.Zhang L, Zhang X, Liu Y, et al. CD146+ Umbilical Cord Mesenchymal Stem Cells...
1.Wang H, Fang K, Yan W, Chang X. T-Cell Immune Imbalance in Rheumatoid Arthritis Is Associated with Alterations in NK Cells and NK-Like T Cells Expressing CD38. J Innate Immun. 2022;14(2):148-166. 2.Zhang L, Zhang X, Liu Y, et al. CD146+ Umbilical Cord Mesenchymal Stem Cells...
近日,来自美国匹兹堡大学医学院的Dario A. A. Vignali 团队在Nature Immunology杂志上发表了一篇题为IFNγ-induction of TH1-like regulatory T cells controls antiviral responses的文章,他们报告了病毒感染在体内促进Treg细胞TH1样极化,从Treg细胞中删除Ifng受体(Ifngr1)可以有效地阻止TH1并诱导TH2 极化。TH2样的If...
Th1-like Tfh cells, but not Th1 cells, are essential for class switching of ZIKV-specific IgG2c antibodies and maintenance of long-term neutralizing antibody responses. Our study suggests that specific modulation of the Th1-like Tfh cell response during infection or vaccination may augment the ...
［Key words］Th1-like Th17cells；Autoimmune diseases；Plasticity of Th17cells 1概述 免疫系统已经进化出复杂的机制，可对微生物入侵者产生迅速而极具破坏性的反应，同时保护宿主组织，这种微妙的平衡主要通过免疫系统2种主要类型的T细胞进行调节，即CD8+T细胞和CD4+T 细胞。CD8+T细胞的任务是杀死被微生物入侵者感 ...