三、Th1/Th2 细胞分化的细胞因子和转录因子 图2 参与Th1和Th2分化的细胞因子和转录因子 Th1和Th2细胞的分化受多种因素的调控,其中细胞因子起着最重要的作用。调节Th2细胞分化的细胞因子主要是IL-4和IL-13,而IFN-α、IL-12和IFN-γ调节Th1细胞分化。此外,最近发现IL-18和T1/ST2产物也参与Th1/Th2细胞分化调...
Also discussed are the roles of Th1 and Th2 cells in some immunopathological conditions, such as autoimmune and neurological disorders, allergy and HIV infection. By combining for the first time complete information on basic mechanisms together with the clinical implications of Th1/Th2-domina...
Th2ratioshowedacleardeviationfromnormalbalance Pt0.01 .INF-)decreased butP<0.05 andIL- 4clearlyincreased Pt0.01 inbloodserumormucosahomogenate. ThechangesofTh2cellsand correlativecytokinesmayplayanimportantroleinthepathogenesisofallergicrhinitis. Rhiniti allergic Tcellsubset Interferon-) Interleukin-4 1 山东...
T helper cells can be subdivided into Th1 and Th2 depending on the cytokines they produce. Th1 cells are characterized by the production of pro-inflammatory cytokines. Furthermore, these cells are involved in cell-mediated immunity. The cytokines are produced by Th1 cells which stimulate the ...
Human T-H-1 cells preferentially develop during infections by intracellular bacteria and trigger phagocyte-mediated host defense, whereas T-H2 cells, which predominate during helminthic infestations and in response to common environmental allergens, are responsible for phagocyte-independent host response. ...
OKT3 activation induced a high expression of CD30 in cells of both Th1 and Th0 as well as Th2 type after 1-3 days. A difference between the clones was noted in that the Th2 clones remained highly positive in CD30 expression, whereas expression in the other clones started to decline ...
Th1/Th2及Th17/Treg平衡在系统性红斑狼疮患者治疗前后变化的研究摘要背景:系统性红斑狼疮(SLE)是一种由多因素参与的以多脏器受累为特征的自身免疫性疾病,免疫调节功能紊乱贯穿其整个发病过程,具体发病机理仍不明确,无特效的治疗药物,患者病情稳定后无明确的实验室指标指导减药或停药。近年研究认为T淋巴细胞异常并引起...
机体清除病原体需要辅助性T细胞的参与,根据其产生细胞因子的不同可将辅助性T细胞分为两类:Th1细胞和Th2细胞。GATA3在调节Th1和Th2细胞分化中起重要作用。转录因子GATA家族(GATA-3)不仅在转录水平上调节Th2类细胞因子的表达,而且在染色体结构的重组和IL-4位点的开放方面都起着重要的作用。作为一个重要的调控,GATA...
in which Th1 producing IL-2 and IFN-γ,can result in the genensis of this disease and make the disease worse.Th2 producing IL-4,IL-5 and IL-10,can suppresse or make the disease better.This article reviews the research on the relationship between Th1/Th2 cells and EAE in recent ...
百度试题 题目Both TH1 and TH2 cells ___.相关知识点: 试题来源: 解析 can prompt class-switching to a sub-class of IgG 反馈 收藏