MMP2TGF beta 1/Smad signalling pathwayBackground: A high-fat diet is a major risk factor for coronary heart diseases. Matrix metalloprotease (MMP) expression is changed in many cardiovascular diseases. Selenium, which is an important trace element in animals, has a close relationship with ...
1 2 BMP •Bonemorphogeneticprotein•Noggin 3 TGF-beta •TGF-β（transforminggrowthfactor）•latencyassociatedpeptide（LAP）4 Overview LAPTGF-betareceptorSmadSBE NATURE|VOL390|4DECEMBER1997 5 latencyassociatedpeptide（LAP）LLCintoECM 6 ReceptortypeIIreceptorSer213,409 typeIreceptor GSdomain,Ser165 ...
I-SmadsSmad6,7SmadsR-Smads receptor-activated SmadsCo-Smad common mediator SmadsRegulationLigandReceptorSmadenter nucleusLigand理化因素Ros, PH, temperature生物因素MMP2,8 proteaseBMP NogginReceptorBAMBIBMP and activin membrane bound inhibi 4、torpseudo-receptorubiquitination(lipid raft) I-Smad - Smurfs (...
1 2 BMP •Bonemorphogeneticprotein•Noggin 3 TGF-beta •TGF-β（transforminggrowthfactor）•latencyassociatedpeptide（LAP）4 Overview LAPTGF-betareceptorSmadSBE NATURE|VOL390|4DECEMBER1997 5 latencyassociatedpeptide（LAP）LLCintoECM 6 ReceptortypeIIreceptorSer213,409 typeIreceptor GSdomain,Ser165 ...
LigandReceptorSmadenternucleus•••Ligand•理化因素Ros,PH,temperature•生物因素proteaseMMP2,8•BMPNogginReceptor•BAMBIBMPandactivinmembraneboundinhibitorpseudo-receptor•ubiquitination(lipidraft)I-Smad-Smurfs(E3泛素连接酶)•endocytosisclat ...
1 2 BMP •Bonemorphogeneticprotein•Noggin 3 TGF-beta •TGF-β（transforminggrowthfactor）•latencyassociatedpeptide（LAP）4 Overview LAPTGF-betareceptorSmadSBE NATURE|VOL390|4DECEMBER1997 5 latencyassociatedpeptide（LAP）LLCintoECM 6 ReceptortypeIIreceptorSer213,409 typeIreceptor GSdomain,Ser165 ...
7SmadsR-Smads receptor-activated SmadsCo-Smad common mediator SmadsRegulationLigandReceptorSmadenter nucleusLigand理化因素Ros, PH, temperature生物因素MMP2,8 proteaseBMP NogginReceptorBAMBIBMP and activin membrane bound inhibitorpseudo-receptorubiquitination(lipid raft) I-Smad - Smurfs (E3泛素连接酶) ...
7 Smads R-Smads receptor-activated Smads Co-Smad common mediator Smads Regulation Ligand Receptor Smad enter nucleus Ligand 理化因素 Ros, PH, temperature 生物因素 MMP2,8 protease BMP Noggin Receptor BAMBI BMP and activin membrane bound inhibitor pseudo-receptor ubiquitination (lipid raft) I-Smad -...
2,3,5,82.Co-SmadSmad43.I-SmadsSmad6,710SmadsR-Smadsreceptor-activatedSmadsCo-SmadcommonmediatorSmads11RegulationLigandReceptorSmadenternucleus12Ligand理化因素Ros,PH,temperature生物因素MMP2,8proteaseBMPNoggin13Receptor•BAMBIBMPandactivinmembraneboundinhibitorpseudo-receptor•ubiquitination(lipidraft)I-Smad...
to fibronectin as catalyzed by a transglutaminase enzyme, providing a alternative mechanism to maintain TGF-β3 in the inactive form.25Active TGF-β is released from LLC cells through the action of numerous ECM molecules, including proteases such as matrix metalloproteinase 2 (MMP2, also known as...