MMP2TGF beta 1/Smad signalling pathwayBackground: A high-fat diet is a major risk factor for coronary heart diseases. Matrix metalloprotease (MMP) expression is changed in many cardiovascular diseases. Selenium, which is an important trace element in animals, has a close relationship with ...
1 2 BMP •Bonemorphogeneticprotein•Noggin 3 TGF-beta •TGF-β（transforminggrowthfactor）•latencyassociatedpeptide（LAP）4 Overview LAPTGF-betareceptorSmadSBE NATURE|VOL390|4DECEMBER1997 5 latencyassociatedpeptide（LAP）LLCintoECM 6 ReceptortypeIIreceptorSer213,409 typeIreceptor GSdomain,Ser165 ...
I-SmadsSmad6,7SmadsR-Smads receptor-activated SmadsCo-Smad common mediator SmadsRegulationLigandReceptorSmadenter nucleusLigand理化因素Ros, PH, temperature生物因素MMP2,8 proteaseBMP NogginReceptorBAMBIBMP and activin membrane bound inhibi 4、torpseudo-receptorubiquitination(lipid raft) I-Smad - Smurfs (...
生物因素proteaseMMP2,8•BMPNogginReceptor•BAMBIBMPandactivinmembraneboundinhibitorpseudo-receptor•ubiquitination(lipidraft)I-Smad-Smurfs(E3泛素连接酶)•endocytosisclat
7SmadsR-Smads receptor-activated SmadsCo-Smad common mediator SmadsRegulationLigandReceptorSmadenter nucleusLigand理化因素Ros, PH, temperature生物因素MMP2,8 proteaseBMP NogginReceptorBAMBIBMP and activin membrane bound inhibitorpseudo-receptorubiquitination(lipid raft) I-Smad - Smurfs (E3泛素连接酶) ...
2,3,5,82.Co-SmadSmad43.I-SmadsSmad6,710SmadsR-Smadsreceptor-activatedSmadsCo-SmadcommonmediatorSmads11RegulationLigandReceptorSmadenternucleus12Ligand理化因素Ros,PH,temperature生物因素MMP2,8proteaseBMPNoggin13Receptor•BAMBIBMPandactivinmembraneboundinhibitorpseudo-receptor•ubiquitination(lipidraft)I-Smad...
Three extracellular matrix (fibroblast environment) enzymes are thought to be involved in the active formation of TGF-β: elastase, metalloprotease 2 (MMP2), and tolloid-like family protease (BMP-1) [10]. Endoglin, a type III TGF-β receptor, is involved in the transmission of the TGF-β...
Betaglycan blocks metastatic behaviours in human granulosa cell tumours by suppressing NFκB-dependent MMP2 expression in spheroid culture models S, Wang Y, Tan HL, Fuller PJ, Findlay JK, Stenvers KL: Betaglycan AltersNFκB-TGFβ2 Cross Talk to Reduce Survival of Human Granulosa Tumor Cells.....
to fibronectin as catalyzed by a transglutaminase enzyme, providing a alternative mechanism to maintain TGF-β3 in the inactive form.25Active TGF-β is released from LLC cells through the action of numerous ECM molecules, including proteases such as matrix metalloproteinase 2 (MMP2, also known as...
The expression of MMP1 was reduced markedly while TIMP1 synthesis was enhanced after BGF treatment. ERK phosphorylation exhibits a significant increase in the mice treated with BGF. Furthermore, BGF can markedly upregulate TGF-β1 expression. The p-smad2 showed 2-fold increases compared with the ...