TGFB2-OT1人类牙龈上皮细胞P.gingivalis细胞自噬目的:牙龈卟啉单胞菌(Porphyromonas gingivalis)是牙周病的主要致病菌之一,其可侵入人类牙龈上皮细胞(human gingival epithelial cells,HGECs),破坏牙周组织的生态平衡,引起免疫炎症反应.前期研究发现,P.gingivalis感染可诱导永生化的HGECs系epi4细胞自噬.长链非编码RNA(long...
TGFB2-OT1 promoted proliferation, migration, invasion, and angiogenesis in HCC cells, both in vitro and in vivo. TGFB2-OT1 binds to β-catenin and competitively impaired the binding of β-catenin to GSK3β, thus suppressing the phosphorylation of β-catenin at Ser33, Ser37, and Thr41....
TGFB2-OT1 acted as a competing endogenous RNA, bound to MIR3960, MIR4488 and MIR4459, then regulated the expression of the miRNA targets CERS1 (ceramide synthase 1), NAT8L (N-acetyltransferase 8-like [GCN5-related, putative]), and LARP1 (La ribonucleoprotein domain family, member 1). ...