结论:TGFB1和TGFBR2基因多态改变可能与中国华东宜兴地区汉族人群胃癌遗传易感性相关。周炎靳光付蒋国军王洪敏谈永飞丁伟良王莉娜陈文森柯巧沈靖癌症:英文版周炎;靳光付;蒋国军;王洪敏;谈永飞;丁伟良;王莉娜;陈文森;柯巧;沈靖;徐耀初;沈洪兵.TGFB1和TGFBR2基因多态与胃癌遗传易感性的关系.癌症:英文版.2007.581-585周炎,...
目的研究TGFB1 C-509T、T+29C和TGFBR2 G-875A与中国女性乳腺癌遗传易感的相关性,并阐述这三个多态位点与不同雌激素受体(ER)、孕激素受体(PR)和人类表皮生长因子受体-2 (HER2)表达水平乳腺癌易感性的关系。 方法从170例乳腺癌组织(包括82例新鲜乳腺癌组织、88例石蜡包埋乳腺癌组织)和178例无肿瘤病史女性的...
IL2,IL10,TGFB1,TGFBR1,TGFBR2,IL17A, andIL17F) affected FL susceptibility (Supplementary Table1). We selected SNVs with previous evidence of functionality, either due to the modulation of immune responses or due to previous associations with cancer development or prognosis....
受体2(Transforming Growth Factor Beta Receptor TypeⅡ,TGFBR2)基因进行基因突变筛查,以明确这些MFS患者FBN1基因和TGFBR2基因突变的情况,并观察基因突变与临床表型之间的关系。 方法:应用PCR分别扩增14例MFS患者FBN1基因的65个外显子和其中11例MFS患者(未发现FBN1...
Several polymorphisms have been identified in TGFB1 and TGFBR2 genes, including those associated with the regulation of TGF-β1 levels and TGF binding to its receptor. The decrease of TGF-β1 levels and the disruption of TGF TGF-β1 signaling can cause abnormal placentation, hypoxia, and ...
Variant alleles of tgfb1 and tgfbr2 are associated with a decreased risk of gastric cancer in a chinese population. Int J Cancer. 2007;120:1330–5.GuangfuJin, LinaWang, WensenChen, ZhibinHu, YanZhou, YongfeiTan, JianmingWang, ZhaolaiHua, WeiliangDing, JingShen, ZuofengZhang, XinruWang, ...
本研究拟探讨中国华东宜兴地区汉族人群TGFβ1基因TGFB1 C-509T和TGFB1 Leu10Pro及其Ⅱ类受体基因TGFBR2 G-875A单核苷酸多态与胃癌遗传易感性的关系。方法:本研究为病例对照研究。选取宜兴胃癌高发区组织学确诊的胃腺癌患者256例及年龄和性别频数匹配的对照健康体检人群303例,以引物错配限制分析PCR(primer-introduced ...
Transforming growth factor-β1 (TGFB1); transforming growth factor-β receptor 1 (TGFBR1; ALK5); TGFBR2 (TGFβ-RII)Studies in human samples suggest inhibiting TGFBR1 or TGFBR2 could help treat allergy-related conditions. Further details on the research, next steps and licensing status are ...
Transforming growth factor-β1 (TGFB1); transforming growth factor-β receptor 1 (TGFBR1; ALK5); TGFBR2 (TGFβ-RII)doi:10.1038/scibx.2013.895Studies in human samples suggest inhibiting TGFBR1 or TGFBR2 could help treat allergy-related conditions.Springer...
89 Influence of functional genetic variants of TGFβ1/TGFβR2 pathway in prostate cancer developmentingentaconnectEUROPEAN JOURNAL OF CANCER -SUPPLEMENT-TeixeiraA.L.RibeiroR.GomesM.PereiraC.LoboF.FragaA.Calais-da-SilvaPinaMedeiros