TGF-β配体和细胞膜上的TGFBR2结合,一旦结合TGFBR2磷酸化并激活TGFBR1;活化的TGFBR1依次磷酸化并激活受体活化的SMADs(R-SMADs:SMAD2和SMAD3);SMAD7和R-SMADs竞争与TGFBR1相互作用,从而阻止R-SMAD的激活和信号的正常传导。 激活的R-SMADs与TGFBR1分离,从而与通用SMAD...
从 CX3CR1GFP/+ 小鼠中分离出成年小胶质细胞和血液单核细胞,并分析其受体水平。作者发现,与血液来源的细胞相比,常驻的成年小胶质细胞表达更高水平的 Tgfbr1,而两种细胞类型中的 Tgfbr2 水平相似(图 2D)。成年小胶质细胞上 Tgfbr1 的较高表达增强了 TGFβ1 与这些常驻骨髓细胞命运的潜在相关性。 由于之前的数...
Methods We examined polymorphisms in the promoter region of the TGFB1 gene as well as the TGFBR1*6A microsatellite in the Nurses' Health Study cohort. Results No overall associations between the L10P polymorphism of TGFB1 or the TGFBR1 microsatellite were detected. However, we observed an ...
Transforming growth factor-β1 (TGFB1); transforming growth factor-β receptor 1 (TGFBR1; ALK5); TGFBR2 (TGFβ-RII)doi:10.1038/scibx.2013.895Studies in human samples suggest inhibiting TGFBR1 or TGFBR2 could help treat allergy-related conditions.Springer...
Studies in rats suggest that inhibiting TGFBR1 and TGFBR2 could help treat epilepsy induced by brain trauma.Springer NatureScience-Business eXchangedoi:10.1038/scibx.2009.1113
RT-PCR analysis of LbetaT2 cells and whole adult murine pituitaries indicated that both expressed itTgfbr1 /itmRNA, but that itTgfbr2 /itwas not detected in LbetaT2 cells. When cells were transfected with a human TGFBR2 expression construct, TGFB1 acquired the ability to significantly stimulate...