Abstract 16407: Transforming Growth Factor-β Type 1 Receptor Gene (TGFBR1) Mutations Impairs Neural Crest Stem Cell (NCSC)-Derived Smooth Muscle Cells Differentiation From Human Pluripotent Stem Cells (hPSCs)doi:10.1161/circ.138.suppl_1.16407
The Experimental & Molecular Medicine TFAP2C- and TGFBR1-mediated lung tumorigenesis W Kim et al 5 Figure 1 TGFBR1 (transforming growth factor-β receptor type 1) was upregulated by TFAP2C (transcription factor-activating enhancer- binding protein 2C) in non-small-cell lung cancer (NSCLC) ...
(1996). Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature 383: 168–172. This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org...
Transforming growth factor-β receptor 1 (TGFBR1) was confirmed as a direct target of regulation by miR-770–5p. The expression of TGFBR1 was significantly increased in pulmonary fibrosis. Knockdown of TGFBR1 blocked the transduction of the TGF-β1 signaling pathway and attenuated the activation ...
p21/p/CAF regulates TGFb transcriptional activity and Smad3 DNA binding p21 has been implicated in the control of gene transcrip- tion by associating with various transcription factors [7], but also regulates estrogen receptor-a-dependent gene expression by activating p300-CREBBP-driven (CBP) [47...
Transforming growth factor beta receptor 3 (TGFBR3), also known as betaglycan, is a member of the TGF-尾 receptor family. In our previous study, bioinformatics analysis revealed that TGFBR3 levels are elevated in patients with Alzheimer's disease (AD) and identified TGFBR3 as a potential ...
Although the expression of Mex3 RNA-binding family member B (MEX3B) is upregulated in human nasal epithelial cells (HNECs) predominately in the eosinophilic chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) subtype, its functions as an RNA binding protein in airway epithelial cells remain...
GATA4 belongs to the zinc finger transcription factor family which consists of six members from GATA 1 to GATA 6. The structure of GATA4 features family-specific two N-terminal transcription activation domains (TAD), two central zinc finger domains (ZF), a nuclear localizing signal (NLS) immed...
GFP+collagen-secreting lung fibroblasts (Fig.6d). Global deletion ofTxndc5, however, prevented the upregulation of TGFBR1 inCol1a1-GFPTgmouse lungs in response to BLM treatment (Fig.6d, e). In addition, treatment with LY364947 (10 μM), a TGFβ receptor 1 kinase inhibitor, abolished...
Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily. It has been demonstrated that FXR is not only expressed in liver and kidney tissues, but also functionally expressed in adult cardiomyocytes and different cell types of the vascular wall22,23. After being activated by ...