To improve the therapeutic index of CA9 CAR T cells, we developed an "AND" logic gated ICT cell that requires the presence of two antigens to trigger tumor cell killing, thereby enhancing tumor specificity. Induction of the CA9 CAR is gated on the expression of PSMA found on the tumor ...
M Pizzato, M Li, J Vignat, M Laversanne, D Singh, C La Vecchia, S Vaccarella The epidemiological landscape of thyroid cancer worldwide: GLOBOCAN estimates for incidence and mortality rates in 2020 Lancet. Diabetes and Endocrinology, 10 (2022), pp. 264-272 https://doi.org/10.1016/S2213...
Kwon T, Youn H, Son B, Kim D, Seong KM, Park Set al. DANGER is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer.Oncotarget2016;7: 7193–7206. PubMedPubMed CentralGoogle Scholar Livak KJ, Schmittgen TD . Analysis of rel...
PTGS2: prostaglandin- endoperoxide synthase 2; SDS: sodium dodecyl sulphate; TβRI: TGFβ type I receptor; TGFβ: transforming growth factor-beta; TSA: trichostatin A Acknowledgements This work was supported by a Canadian Institutes for Health Research (CIHR) grant (fund code 230670 to JJL)....
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(n = 3); *Po0.05 compared with normal lung tissues; Student's t-test. Pearson's correlation scatter plot of the fold change in the levels of TFAP2C and TGFBR1 mRNA in normal and tumor tissues of lung cancer patients is shown (bottom). (d) The protein levels of TFAP2C and TGFBR1 ...