纤维化疾病模型构建与干预在肝纤维化、肺纤维化等疾病中，TGF-beta 1通过激活成纤维细胞和胶原沉积驱动病理进程。重组蛋白用于构建体外和动物模型（如CCl4诱导的肝纤维化），评估抗纤维化药物的疗效。免疫调节与炎症反应研究TGF-beta 1在调节Th17/Treg细胞平衡中起关键作用，其重组蛋白被用于诱导Th17细胞分化，探索自身...
LRRC33/NRROS 影响巨噬细胞和小胶质细胞中 TGF-β-1 的激活,而 LRRC32/GARP 控制激活的调节性 T 细胞 (Treg) 的激活。此外,与整合素(ITGAV:ITGB6 或 ITGAV:ITGB8)的相互作用会诱导 LAP 的构象变化,导致活性 TGF-β-1 的释放。这种动态相互作用凸显了 LAP 在各种生理环境中协调 TGF-β-1 受控激活中的...
TregTGF-beta 1Transwell assayIL-10Background and aim: Literature on the role of Regulatory T cells (Tregs) in acute viral infections is limited. Having established that the Tregs in self-limiting hepatitis E infection are elevated and functional, this study has focused on characterizing the ...
humanNeutralization,IHC Am J Pathol Latent-transforming growth factor β-binding protein 1/Transforming growth factor β1 complex drives antitumoral effects upon ERK5 targeting in melanoma Sci Rep Treg-derived TGF-β1 dampens cGAS-STING signaling to downregulate the expression of class I MHC complex...
说明: 转化生长因子β1(TGF-b1)是细胞因子TGF-beta超家族的成员。该家族的成员在免疫,增殖,粘附,迁移和生长抑制途径中表现出调节活性。TGF-b1通过TGF-bRI和TGF-bRII受体通过SMAD蛋白发出信号。除重组IL-2外,TGF-b1还经常用于在细胞培养中生产Treg细胞。
Zuniga, J.E.et al.(2005) J. Mol. Biol.354:1052. Long Name Latency-associated Peptide Entrez Gene IDs 7040 (Human) Alternate Names CED; DPD1; LAP (TGFbeta 1); LAP (TGF-beta 1); LAP; TGFB; TGFB1; TGFbeta; transforming growth factor beta 1 ...
Dendritic cells exposed to tumors have been reported to secrete TGF beta 1 and stimulate the differntiation of CD4+CD25+ Treg cells from peripheral CD4+CD25- progeny. TGF beta 1-induced regulatory T cells have been termed iTreg. 产品留言 标题 联系人 联系电话 内容 验证码 点击换...
与LRRC32/GARP的相互作用控制活化的调节性t细胞(treg)表面tgf - β -1的激活。与整合素(ITGAV:ITGB6或ITGAV:ITGB8)的相互作用导致了潜伏期相关肽链的扭曲和随后活性TGF-beta-1的释放。多功能蛋白,调节多种细胞类型的生长和分化,参与正常发育、小胶质细胞功能和神经退行性变反应等多种过程。成熟形态的激活遵循不...
PE anti-mouse LAP (TGF-β1) Antibody - Transforming growth factor beta (TGF-β) is a cytokine that has critical functions in immune response by regulating Treg and Th17 cells.
expansion of naturally-occurring T reg cells. Moreover, TGF-beta1 has been shown to act as a costimulatory factor for expression of Foxp3, leading to the differentiation of CD4+CD25+ Treg cells from peripheral CD4+CD25- progeny. TGF-beta-induced regulatory T cells have been termed Ti-Treg....