M7824(全称Anti-PD-L1/TGFbeta trap,代码MSB0011359C),来自Merck Serono的双抗产品,有人将PDL1/TGFβ称为2.0版本的PD-1,它在非小细胞肺癌、HPV相关癌症、胃癌等领域都展示出惊艳的临床数据,Merck更是雄心勃勃地打算将其与Keytruda做头对头试验,一场王者对决即将开启。它的作用机理是什么?它的早期临床数据如何?...
Programmed death-ligand 1 (PD-L1) is a ligand of programmed death-1 (PD-1), an immune checkpoint receptor, allowing tumor cells to avoid elimination by immune cells. Recently, targeting the TGF-β signaling and PD-L1 pathways has emerged as a strategy for cancer therapy. In this review,...
SHR-1701 is a bifunctional fusion protein that is a PD-L1 monoclonal antibody fused with the extracellular TGF-βRII domain. This agent has promising antitumor efficacy in advanced cervical cancer [292,293]. Among 32 patients with cervical cancer, the objective response rate is 15.6%, and the ...
由于肿瘤和自身免疫性疾病同属免疫学范畴,许多靶点药物的主要治疗领域既包括肿瘤,也包括自身免疫性疾病,如BTK抑制剂、PD-1、PD-L1等。 “劲方医药现有7至8个研发管线,覆盖肿瘤免疫和自身免疫性疾病,公司可以针对同一靶点研发治疗肿瘤和自身免疫性疾病的药物,达到事半功倍的效果。”郑彪博士谈道。 TGF-βR1抑制剂...
The programmed site-specific delivery of LY3200882 and PD-L1 siRNA boosts immunotherapy for triple-negative breast cancer by remodeling tumor microenvironment. Authors - Pan Zhang View Article mouse cell culture supernatants Adv Healthc Mater Releasable, Immune-Instructive, Bioinspired Multilayer Coating Re...
存储条件:在 -20°C 下可保存 2 年。复溶后,在 4°C 下可稳定保存 1 周,在 -20°C 下可稳定保存更长时间(含载体蛋白)。建议将等分试样在 -20°C 或 -80°C 下冷冻以延长保存时间。 运输条件:美国大陆的室温;其他地方可能有所不同。 产品活性:Transforming growth factor beta-1 proprotein 是 Latenc...
Examples of such agents include inhibitors of PD-1 or PD-L1 (B7-H1), such as anti-PD-1 antibodies, including nivolumab (Bristol-Myers Squibb) and pembrolizumab, also known as MK-3475 (Merck), pidilizumab (Curetech), AMP-224 (Amplimmune), and anti-PD-L1 antibodies, including MPDL32...
PDCD1LG2 Others Mouse小鼠B7-DC / PD-L2 / CD273人细胞裂解液(阳性对照)壬基-β-D-葡萄吡喃糖甙(>98%,BC)质量规格:>98%,BCNonylβ-D-glucopyranoside HuTu-80人十二指肠腺癌细胞N-苄基甘氨酸盐酸盐质量规格:美国进口N-Benzylglycine 公司简介
Cancer Commun (Lond) Anti‐PD‐L1/TGF‐βR fusion protein (SHR‐1701) overcomes disrupted lymphocyte recovery‐induced resistance to PD‐1/PD‐L1 inhibitors in lung cancer Pubmed:34981670 Polymers (Basel) 3D Printed Scaffold Based on Type I Collagen/PLGA_TGF-β1 Nanoparticles Mimicking the Growt...
1017-MP-025/CF 25 UG Recombinant Mouse CCL24/Eotaxin-2/MPIF-2 (aa 27-119), CF (25 UG) 1019-B7-100 100 UG Recombinant Mouse B7-H1/PD-L1/Fc Chimera, CF (100 UG) 102-B2-001 1 UG Porcine TGF-beta 2 (1 UG)产品搜索请输入产品名称 产品...