Oncology TGFbeta1and BMP7 regulation of chondrogenesis in mesenchymal stem cells derived from embryonic stem cells THE UNIVERSITY OF WISCONSIN - MADISON Wan-Ju Li BrownPatrick ThomasFor decades, mesenchymal stem cells (MSCs) have served an important role in stem cell research, particularly in the ...
Latent TGF beta 1 (latent TGFB1) 是 TGF-B1 的非活性形式。Latent TGF beta 1 通过 LTBP 与细胞外基质 (ECM) 结合。LTBP 是 ECM 的组成部分,因此 LTBP 的蛋白水解裂解可导致 latent TGF-β 1 从基质中释放。此外,活性 TGFB1 的蛋白水解和释放是由 BMP-1 和多种基质金属蛋白酶介导的 。Latent TGF ...
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formation has been reported for BMP-2, BMP-7, and Nodal [17,18]. TGF-β proteins are always translated together with their pro-peptide portions which can have varying size and sequence; it is the sequence of the mature proteins that creates similarity among family members. The ...
sufficient to significantly inhibit both TGF-beta and BMP signal transduction and results in the differential expression of a broad subset of target genes likely to underlie tumor formation both from the mesenchymal and epithelial compartments... P Alberici,C Gaspar,P Franken,... - 《Pathogenetics...
R&D 314-BP-010 R&D Recombinant Human BMP-4 (10 UG KIT 5480 R&D 233-FB-025/CF Recombinant Human FGF basic (146 aa), CF KIT 2270 R&D 216-MC-025/CF R&D Recombinant Human M-CSF, CF KIT 6300 R&D NL009 R&D Donkey Anti-Mouse IgG NL493 Affinity Purified PAb KIT 1450 R&D 3139-FB-025...
Interestingly, BMP2, one of the evaluation marker of osteoblast differentiation, was reported to be a cytokine of TGF-beta family [23]. Subsequently, expression of two genes enriched in TGF-beta family was downregulated in DEX-induced osteoporosis cells. These results indicated that CCNA1 may ...
关键词: Cartilage Chondrocyte Osteoarthritis Growth factors BMP TGF DOI: 10.1007/s00223-009-9311-1 被引量: 52 年份: 2010 收藏 引用 批量引用 报错 分享 全部来源 求助全文 Springer 国家科技图书文献中心 (权威机构) EBSCO Semantic Scholar 掌桥科研 查看更多 相似文献 参考文献 引证文献...