Extracellular Matrix ProteinsExtracellular matrix (ECM) is an important determinant of cellular behavior, regulating cellular adhesion, cellular migration, cellular proliferation, and cellular differentiation. Increasingly, it has become appreciated that certain of these actions of ECM derive from its ability...
TGF-β1在正常的肝脏细胞中主要分布在Kupffer细胞中，其次为肝星状细胞（HSC），在纤维化的肝脏中TGF-β1 mRNA在HSC的表达会明显增多。目前认为HSC是ECM的主要来源，而TGF-β1是引起肝纤维化最重要的细胞因子之一。TGF-β1是提高肝纤维化最有效的细胞因子, 能够抑制肝细胞的增殖, 激发HSC的活化, 促进ECM的产生...
此外，TGF-β 还负责调节肿瘤微环境 (TME) 中的基质细胞。小 M 之前在《靶向肿瘤微环境》中提到，TME 由多种类型的基质细胞 (如成纤维细胞、淋巴细胞、巨噬细胞)、免疫细胞 (如 T/B 细胞) 和细胞外成分 (如细胞外基质 ECM) 组成。TGF-β 由癌症和基质细胞表达，包括癌症相关成纤维细胞 (CAF)。TGF-β ...
目前认为HSC是ECM的主要来源,而TGF-β1是引起肝纤维化最重要的细胞因子之一。TGF-β1是提高肝纤维化最有效的细胞因子, 能够抑制肝细胞的增殖, 激发HSC的活化, 促进ECM的产生, 并调节肝细胞的凋亡。 在创伤愈合中,角质行程细胞在伤口边缘发生EMT。 III型: ...
它在调节细胞迁移、血管生成、上皮间质转化、细胞凋亡、免疫功能调节、细胞外基质(ECM)产生和ECM重塑调节等方面具有重要作用;肿瘤生长和维持通常需要的生物过程[1][2]。 与该家族的所有成员一样,TGF-β3 高度保守跨物种,小鼠、大鼠和人类 TGF-β3 表现出 >97% 的序列同源性。 TGF-β3 通过整合素从 LAP 释放...
Latent TGF beta 1 通过 LTBP 与细胞外基质 (ECM) 结合。LTBP 是 ECM 的组成部分,因此 LTBP 的蛋白水解裂解可导致 latent TGF-β 1 从基质中释放。此外,活性 TGFB1 的蛋白水解和释放是由 BMP-1 和多种基质金属蛋白酶介导的 。Latent TGF beta 1/TGFB1 Protein, Rat (HEK293, C-His) 是重组的 潜在 ...
ECM deposition is the main characteristic and initial process during fibrosis. TGF-β stimulates the activation and proliferation of fibroblasts, leading to ECM deposition and abnormal organ functions. During this physiological and pathological process, fibroblasts are the main cell types. TGF-β influenc...
TGF-β increases expression of FGF and various ECM components, including MMP-2, which remodels the ECM by digestion of collagen type IV and laminin, fibronectin,α-SMA and collagen type I [27]. Furthermore, overexpression of MMP-2 induces LEC transformation evident by α-SMA expression. Show...
Transforming growth factor-beta (TGF-beta) is a potent fibrotic factor responsible for the synthesis of extracellular matrix (ECM) and is implicated as the major determinant in pathogenesis of chronic fibroses, including kidney. The novel small compound SMP-534 reduced ECM production induced by TGF...