TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma. Cell Cycle. 6, 1360-1366.Honjo Y, Bian Y, Kawakami K, Molinolo A, Longenecker G, Boppana R, Larsson J, Karlsson S, Gutkind JS, Puri RK, Kulkarni AB (2007) TGF-beta receptor I conditional knock...
Biology of TGF-beta in knockout and transgenic mouse models. This paper reviews the basic biology and biochemistry of the TGF-beta isoforms including their unique serine-threonine receptors and signaling intermediate... EP Böttinger,JJ Letterio,AB Roberts - 《Kidney International》 被引量: 432...
combined RNAscope/IHC analysis to examine the cellular expression pattern ofTgfb1in the adult mouse brain. Our data show that, indeed,Tgfb1mRNA is enriched in IBA1-positive microglia but is not detected in neurons (Supplementary Fig.1E).Tgfb1mRNA is also detected in a small population of no...
Connective tissue growth factor/CCN2 overexpression in mouse synovial lining results in transient fibrosis and cartilage damage Arthritis Rheum, 54 (5) (2006 May), pp. 1653-1661 92 N.A. Wahab, B.S. Weston, R.M. Mason Modulation of the TGFbeta/Smad signaling pathway in mesangial cells by...
The phenotype of the transforming growth factor beta 1 (TGF-beta 1) null mouse has been previously described and is characterized by inflammatory infiltrat... A,G,Geiser,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 1308发表: 1993年 N-...
Moreover, inducible knockout of the TGF-β type II receptor in MSPCs inhibits HO progression in HO mouse models. Our study points toward elevated levels of active TGF-β as inducers and promoters of ectopic bone formation, and suggest that TGF-β might be a therapeutic target in HO....
Akhurst RJ: TGF-beta antagonists: why suppress a tumor suppressor?. J Clin Invest. 2002, 109: 1533-1536. Article PubMed Central CAS PubMed Google Scholar Amendt C, Schirmacher P, Weber H, Blessing M: Expression of a dominant negative type II TGF-beta receptor in mouse skin results in...
We have investigated how the Arf gene product, p19Arf, is activated by Tgfβ during mouse embryo development to better understand how this important tumor suppressor is controlled. Taking advantage of new mouse models, we provide genetic evidence that Arf lies downstream of Tgfβ...
Stimulation of mouse CD4+ T cells in the presence of TGF-β results in the expression of Foxp3 and induction of Treg function. Stimulatio... EM Shevach,Dat. Q. Tran,TS Davidson,... - 《Other》 被引量: 0发表: 2008年 Tumor-derived TGF-beta mediates conversion of CD4+Foxp3+ regulator...
Dunker N, Schmitt K, Krieglstein K: TGF-beta is required for programmed cell death in interdigital webs of the developing mouse limb. Mech Dev. 2002, 113 (2): 111-120. 10.1016/S0925-4773(02)00015-1. Article CAS PubMed Google Scholar Ganan Y, Macias D, Duterque-Coquillaud M, Ros...