TNFR2 knockout mice showed significantly decreased tumor size and weight as well as schizophrenia-like behaviors compared to wild-type mice. Consistent with the reduced tumor growth and SCZ-like behaviors, the levels of TrkB and BDNF expression were significantly decreased in the lung tumor tissues...
Knockout and transgenic mouse models have effectively helped studies of various neurological conditions (reviewed in [34]). To give only a few examples, we have learned that a non-functional p53 expression is protective, P-selectin has a role pathology, TNF is neuroprotective, thioredoxin reduces...
a, Nucleotide sequences (5′ to 3′) of CRISPR gRNAs flanking the interferon receptor (Ifnr) locus on mouse chromosome 16 (MMU16), as used in generating knockout alleles. b, PCR strategy used to screen mutant mice for large chromosomal rearrangements on MMU16 with primer nucleotide sequence...
The aim of our study was to evaluate in vivo the therapeutic efficacy of genetic inhibition of TNF-alpha using TNF-R1 knockout mice in an experimental model of spinal cord trauma. Spinal cord injury was induced by the application of vascular clips to the dura via a four-level T5-T8 lamin...
Altered Heat Stroke Inflammatory Responses in TNF Double Receptor Knockout Mice Tumor necrosis factor double receptor (TNFR) knockout (KO) mice show enhanced heat stroke (HS) mortality compared to wild-type (WT; B6129F) controls. We hypothesized that higher mortality rates are due to alterations...
Tnfsf6gld1generalized lymphoproliferative diseasetumor necrosis factor (ligand) superfamily, member 6Takahashiet al. (1994)TNFSF61 q23autoimmune lymphoproliferative syndrome (ALPS), type 1B (*134638,#601859) a An asterisk (*) before an OMIM number means that the phenotype determined by the gene ...
Genomic profiling of TNT-alpha receptor and IL1 receptor knockout mice reveals a link between the TNF-alpha signaling and increased severity of 1918 pandemic influenza virus infection The influenza pandemic of 1918-1919 was one of the worst global pandemics in recent history. The highly pathogenic...
Human scavenger receptor class B i.p. route: Intraperitoneal route IFNA: Alpha-interferon IFNG: Gamma-interferon IHC staining: Immunohistochemical staining KO: Knockout Poly (I:C)-HMW: Poly (I:C) with high molecular weight Poly (I:C)-LMW: Poly (I:C) with low molecular weight...
IHC of NGAL confirmed that diabetes could induce NGAL expression in the tubular area of kidney tissues, and also confirmed that NGAL was not expressed in knockout mice. Fibrosis is an important driving factor for glomerulosclerosis.In vitro, under HG and TGF-β1 stimulation, HK2 cells with NGAL...
7.3.9TR4. nuclear receptor knockout mouse Hepatic TR4 is a member of the nuclear receptor superfamily and is suggested to be involved in the regulation of lipogenesis and insulin sensitivity[108]. Mice deficient in TR4 have a markedly reduced hepatic SCD1 expression compared to controls[108]....