The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis. 仅用于科研。不用于诊断过程。未经明确授权不得转售。
The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis. 仅用于科研。不用于诊断过程。未经明确授权不得转售。
Beta-type subfamily growth factors are homodimeric or heterodimeric polypeptides with multiple regulatory properties depending on cell type, growth conditions and presence of other polypeptide growth factors. Since their expression is also controlled by distinct promoters, their secretion is temporal and tis...
英文别名:LAP;Latency-associatedpeptide;ARVD;BSC1cellgrowthinhibitor;CED;Cetermin;Diaphysealdysplasia1progressive;DPD1;DPD1;GTSF;GlioblastomaderivedTcellsuppressorfactor;LAP;Polyergin;TGFbeta1;TGFbeta1protein;TGFbeta;TGFbeta1;TGF-beta-1;TGFB1;TGFB;TGFB1;TGFB1_HUMAN;TGFbeta;Transforminggrowthfactor;Tran...
免疫原:KLH conjugated synthetic peptide derived from human TGF beta 1 宿主:详见说明书 用途:仅供科研实验使用 保质期:说明书 应用范围:详见说明书 产地:国产 标记物:Unconjugated 品牌:翊立飒 包装规格:50ul、100ul、200ul 抗原来源:Rabbit 适应物种:Human,?Mouse,?Rat,?Dog,?Pig,?Rabbit,?Sheep,?GuineaPig...
Transforming growth factor-beta (TGF-β) is extensively implicated in the pathogenesis of various types of fibrosis, including subretinal fibrosis, while TGF-β2 was shown to be more highly expressed than other TGF-β isoforms7,12,18,19. As a common mechanism of the mesenchymal transition ...
Sign in to download full-size image 2.3.Activation of latent TGFβ1. (a) TGFβ1 is secreted in a ECM-bound large latent complex (LLC), consisting of TGFβ1 and the latency associated peptide (LAP) that form the small latent complex (SLC), and the latent TGFβ1 – binding protein (...
TGF-beta and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease. Bone Res. 4, 16009 (2016). Article PubMed PubMed Central Google Scholar Guo, X. & Wang, X. F. Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res. 19, 71...
Transforming growth factor beta (TGFβ) is a multi-functional cytokine that regulates cell proliferation, differentiation, migration and survival. It plays a critical role in development, wound healing and immune responses through its regulatory effects on many cell types including epithelial and hematopo...
High-grade tumours and those with lymph node metastases showed higher rates of TAMs and lower expression of TGF-beta1. Loss of nuclear Smad4 expression in tumor was associated with presence of lymph node metastasis, but no influence on prognosis could be demonstrated. Decrease of both TGF-beta...