The aim of the study was to determine the levels of TGF-beta1 in the group of advanced breast cancer, in which increased TGF-beta1 levels were most likely to be expected. TGF-beta1 levels were also compared with estradiol levels. Our results suggested that TGF-beta1 synthesis may be ...
The mechanism(s) in which transforming growth factor beta 1 (TGFβ) modulates autophagy in cancer remain unclear. Here, we characterized the TGFβ signaling pathways that induce autophagy in non-small cell lung cancer cells, using cells lines stably expressing GFP-LC3-RFP-LC3ΔG constructs that ...
Transforming Growth Factor Beta The TGF-β family of cytokines regulates cell proliferation, differentiation, recognition, and death via serine/threonine kinase activity receptors. The TGF-β1, TGF-β2, and TGF-β3 have been identified in the developing lung where they have been shown to stimulate...
Mutational inactivation of transforming growth factor beta (TGF-β) signalling is crucial during PDAC progression and affects 40–50% of patients [4]. Rescuing TGF-β signalling in human PDAC cells abrogates their proliferation and tumourigenicity, implying that TGF-β signalling exerts tumour-suppres...
Two Faces of TGF-Beta1 in Breast Cancer. Mediators Inflamm. 2014;2014:141747. Article PubMed PubMed Central Google Scholar Heldin CH, Landström M, Moustakas A. Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelialmesenchymal transition. Curr Opin Cell Biol. 2009;21:...
First Hospital of Handan ， Handan Hebei 056004， China ）Abstract: Objective To investigate the levels of serum tissue inhibitor of metalloproteinase -1 （TIMP -1） and transforming growth factor -beta1 （TGF -β1） in lying -in woman with re -pregnancy of scar uterus and their predictive...
NF-kB Transcription Factor Rhoa Transforming Growth Factor Beta (TGFbeta) Introduction TGF-β is a signal protein that regulates many cellular functions, including cell proliferation, differentiation, migration, and survival as well as development, carcinogenesis, fibrosis, wound healing, and the immune...
Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma. Am J Pathol 1993; 143: 381–389. CAS PubMed PubMed Central Google Scholar Chod J, Zavadova E, Halaska MJ, Strnad P...
High serum transforming growth factor-beta 1 levels predict outcome in hepatocellular carcinoma patients treated with sorafenib. Clin Cancer Res. 2015;21(16):3678–84. Article CAS PubMed Google Scholar Coskun HSI, Ozcan M, Ayaz S, Dalva K, Ustun C, Arat M. Serum transforming growth factor...
[5] Wang W, Koka V, Lan HY. Transforming growth factor-beta and Smad signalling in kidney diseases. Nephrology (Carlton), 2005, 10:48-56. [7] Bowen T, Jenkins RH, Fraser DJ. MicroRNAs, transforming growth factor beta-1, and tissue fibrosis. J Pathol, 2013, 229:274-285. [8] Li ...