TGF-beta is known to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. Connective tissue growth factor (CTGF), which is induced by TGF-beta, has been reported to mediate stimulatory ...
All 15 cases of desmoid tumors were positive for TGF-beta and CTGF. The real-time polymerase chain reaction showed higher expression levels of TGF-beta and CTGF in desmoid fibromatosis compared with normal skin. The high constitutive expression of beta-catenin downstream effectors; TGF-beta, CTGF...
TGF-beta- and CTGF-me- diated fibroblast recruitment influences early outward vein graft remodeling. Am J Physiol Heart Circ Physiol. 2007;293: H482-488.Jiang Z, Yu P, Tao M, et al. TGF-β- and CTGF-mediated fibroblast recruitment influences early outward vein graft remodeling. Am J ...
CTGF levels are induced subsequent to TGF-β, remaining elevated upon the onset of fibrosis with kinetics similar to TGF-βRII. Collectively, our studies suggest that alterations in TGF-β receptor levels may be a common mechanism in tissue fibrosis by which TGF-β upegulates its signaling ...
Losartan improves resistance artery lesions and prevents CTGF and TGF-beta production in mild hypertensive patients. Kidney Int 2006;69:1237-1244.Gómez-Garre D, Martín-Ventura JL, Granados R, et al. Losartan improves resistance artery lesions and prevents CTGF and TGF- β production in mild ...
Novel insights into TGF-beta and activin a dependent early expression of connective tissue growth factor (CTGF/CCN2)Olav GressnerBirgit LahmeMonika SiluschekKatharina RehbeinRalf WeiskirchenAxel M. Gressner
- TGF-Beta and CTGF Induce Alpha2 (1) Collagen Expression By Regulating C-myc And Miz1K. Takehara
505-P: ROCK2 Regulates TGF-Beta-Induced Expression of CTGF and Profibrotic Genes via NF-kappa B and Cytoskeleton Dynamics in the Mesangial CellsThe small GTPase Rho and its effector Rho-kinase are involved in the pathogenesis of diabetic kidney disease. Accumulating evidence shows pro...
Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes. J Hepatol 2007;47:699-710.Gressner OA,Lahme B,Demirci I. Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2)expression in hepatic ...
- Anti-Fibrotic Effects of Microrna-145 in Systemic Sclerosis Via a Multi-Step Regulation of TGF-Beta/CTGF SignalingSerena Vettori