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The importance of transforming growth factor-beta-1 (TGF-β1) in immunoregulation and tolerance has been increasingly recognized. It is now proposed that there are populations of regulatory T cells (T-reg), some designated T-helper type 3 (Th3), that exert their action primarily by secreting ...
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Abnormal accumulation of the amyloid-beta peptide (Abeta) in the brain appears crucial to pathogenesis in all forms of Alzheimer disease (AD), but the underlying mechanisms in the sporadic forms of AD remain unknown. Transforming growth factor beta1 (TGF-beta1), a key regulator of the brain...
Since TGF-β1 is involved in cellular proliferation/development, the aim of this work was to analyze the expression of TGF-β1, its receptors TGFBRII, TGFBRI (ALK-1 and ALK-5), and the co-receptor endoglin in human biopsies from patients with idiopathic infertility. Methods Specific ...
TGF-beta 1 and TGF-beta 2 abundance in liver diseases of mice and men 作者:Dropmann Anne; Dediulia Tatjana; Breitkopf Heinlein Katja; Korhonen Hanna; Janicot Michel; Weber Susanne N; Thomas Maria; Piiper Albrecht; Bertran Esther; Fabregat Isabel; Abshagen Kerstin; Hess Jochen; Angel Peter;...
Background and ObjectiveConnective tissue growth factor (CTGF) is a downstream mediator of transforming growth factor-beta1 (TGF-β1), and TGF-β1-induced CTGF expression is regulated through the SMAD pathway. CTGF is implicated in the d... S.,Li,S.,... - 《Journal of Periodontal Resear...
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Multiple sclerosis (MS) is a chronic and degenerative disease that impacts central nervous system (CNS) function. One of the major characteristics of the disease is the presence of regions lacking myelin and an oxidative and inflammatory environment. TGF-β1 and Nrf2 proteins play a fundamental ro...
We have also demonstrated that Transforming Growth Factor-ββ1 (TGF-ββ1) localizes to FN fibrils, and disruption of FN assembly or disruption of TGF-ββ1 localization to FN fibrils attenuates EMT. Previous studies have shown that TGF-ββ1 induces spatial gradients of EMT in mammary ...