Smad3TGF beta 1tongue squamous cell carcinomaBACKGROUND: TGF beta 1 and Smad3 play an important role in the process of EMT. TGF beta 1 regulates the expression of Jagged1 by modulating Notch signaling. Jagged1 is related to tumor invasion, metastasis, chemotherapy resistance, and tumor immune...
Notch activation inhibits TGFbeta/Smad1 and TGFbeta/Smad2 signaling pathways by decreasing the expression of Smad1 and Smad2 and their target genes. In contrast, Notch increases SMAD3 mRNA expression and protein half-life and regulates ... Y Fu,A Chang,L Chang,... - 《Journal of Biological...
TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins. It is now clear that resident myofibroblasts play a central role in the mediation of tissue fibrosis. The aim of the work outlined in this study is to incr... RA Evans,Y.a Chung Tian,R Steadman,...
TGF-beta 1/Smad3Prolactinomas are the most common functional pituitary adenomas. While dopamine agonists are a primary method of therapeutic treatment, the rate of resistance to these drugs continues to increase each year. During previous long-term clinical investigations, we found that partial ...
However, the TGF-[beta]1 protein expression and the effect of TGF-[beta]1/Smad3 signaling on CCl 4 -induced acute liver injury are still unclear. Therefore, in the present study, the level of TGF-[beta]1 protein in serum and hepatic tissue homogenate of...
Smad3 mediates immediate early induction of Id1 by TGF-beta. Liang Yao-Yun,Brunicardi F Charles,Lin Xia. Cell Research . 2008Liang YY, Brunicardi FC, Lin X. Smad3 mediates immediate early induction of Id1 by TGF-beta. Cell Res. 2009;19:140-8....
The expression of TGF-1 and markers of epithelial cells and mesenchymal cells were analyzed. The influences of miR-425 on the development of TNBC through inducing EMT by targeting the TGF-1/SMAD3 signaling pathway in TNBC cell lines were investigated. Furthermore, xenograft mice were used to ...
Expression of transforming growth factor beta 1 (TGF-尾1) was downregulated, while that of TGF-尾2, Mothers against decapentaplegic homolog 3 (SMAD3), ... C Li,Z Peng,Y Zhou,... - 《Bone & Joint Research》 被引量: 0发表: 2021年 Transforming growth factor-beta 1 promotes fibrosis but...
Xu G;Chakraborty G;Lala PK.Restoration of TGF beta regulation of plasminogen activator inhibitor - 1 in Smad3 - reatituted human ehoriocareinoma cell.Biochem Biophys Res Commun.2002.1079-1086Xu G, Chakraborty C, Lala PK. Restoration of TGF-beta regulation of plasminogen activator inhibitor-1 ...
In this study, we identified that the natural compound, neohesperidin, antagonizes TGF-beta 1/Smad3 signaling. We found that neohesperidin not only inhibited the TGF-beta 1-induced injury to alveolar epithelial cells but also decreased the TGF-beta 1-induced myofibroblast differentiation, ...