Notch activation inhibits TGFbeta/Smad1 and TGFbeta/Smad2 signaling pathways by decreasing the expression of Smad1 and Smad2 and their target genes. In contrast, Notch increases SMAD3 mRNA expression and protein half-life and regulates ... Y Fu,A Chang,L Chang,... - 《Journal of Biological...
蛋白表达明显下降,而Smad7 表达明显升高。提示益气活血 方可以下调 TGF β、Smad2 和上调 Smad7 的表达来抑制 CT GF 的表达,进而遏制肾纤维化的进程。 3 思考与展望 TGF β1 / Smad 信号传导通路是肾间质纤维化发生发展 重要的通路,抑制TGF β1 对靶基因的影响被认为是防止肾 纤维化的关键治疗措施之一 [...
Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. RATIONALE: Cardiac fibroblasts are key effector cells in the pathogenesis of cardiac fibrosis. Transforming growth factor (TGF)-beta/Smad3 signaling is act... M Dobaczewski,M Bujak,N Li,... - ...
体外研究 TGFB1(1-1 ng/ml, 6 min)可诱导CLENDO细胞中SMAD2和SMAD3的磷酸化。 TGFB1(1 ng/mL)显著降低了基础和胎牛血清刺激的DNA合成,而不降低细胞活力。 TGFB1(1 ng/mL)可减少CLENDO细胞迁移,导致细胞连接处VE-cadherin丢失。 体内研究 TGF-β1 (1 ng/ μL, 2 μL, i.c.v)可显著阻断(R)-氯...
They include Smad2 and Smad3, which are recognized by TGF-beta and activin receptors, and Smads 1, 5, 8, and 9, which are recognized by bone ... DA Groneberg,H Witt,IM Adcock,... - 《Experimental Lung Research》 被引量: 142发表: 2004年 Tgf-beta 1, activin receptors 1 and 3 Po...
receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different ...
Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem c... Adult mesenchymal stem cells (MSCs) derived from bone marrow contribute to the regeneration of multiple types of mesenchymal tissues. Here we...
SMAD protein phosphorylation negative regulation of macrophage cytokine production oligodendrocyte development cell growth regulation of striated muscle tissue development cell migration regulation of transforming growth factor beta receptor signaling pathway evasion or tolerance of host defenses by virus negative ...
The influences of miR-425 on the development of TNBC through inducing EMT by targeting the TGF-1/SMAD3 signaling pathway in TNBC cell lines were investigated. Furthermore, xenograft mice were used to explore the potential roles of miR-425 on EMT and the development of TNBC in vivo. Results...
Transient transfection studies demonstrate for the first time that TGF g -1 downregulates both DMP-1 and DSPP genes. Our findings indicate that the TGF g -1 type I receptor ALK5 is expressed by odontoblasts as well as the signal transduction proteins Smad2, Smad3, and Smad4. ...