Smad2Smad3信号传导分子基因家族卵巢甾体激素旁分泌自分泌除去内分泌的基本调节作用以外,旁分泌/自分泌生长因子的作用也在生殖调控中有着极其重要的意义,并且与卵巢肿瘤的发生和演变密切相关。TGFβ(Transforming growth factor beta)超基因家族即是其中之一。该家族包括:TGFβ,Activin,inhibin,GDF-9,BMP,MIS等成员。
We conclude that TGF-β/Smad3 signaling blockade enhances energy metabolism in hepatic tissues and ameliorates diet-induced obesity and diabetes. We believe that these findings support the investigational use of anti-TGF-β/Smad3 approaches for management and therapy of diabetes and obesity....
Ellagic acid induces cell cycle arrest and apoptosis through TGF-beta/Smad3 signaling pathway in human breast cancer MCF-7 cells. Int J Oncol. 2015;46:1730-8.Chen HS, Bai MH, Zhang T, et al. Ellagic acid induces cell cycle ... HS Chen,MH Bai,T Zhang,... - 《International Journal...
Smad3/AP-1 interactions control transcriptional responses to TGF-β in a promoter-specific manner. leider RJ, Uitto J, Roberts AB, Mauviel A (2001) Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner. ... Verrecchia,Franck,Vindevoghel,... - ...
Transforming growth factor-beta (TGF-beta) signaling is mediated from serine/threonine kinase receptors to transcriptional responses via Smad proteins. Here comparison of mRNA expression of Smad3–7 in mouse embryos (E9-E15) revealed developmentally regulated distinct expression patterns for Smad3, 4,...
Click to launch & play an online audio visual presentation by Prof. Joan Massagué on SMAD phosphorylation and the TGF-beta pathway, part of a collection of multimedia lectures.
Smad transcription factors mediate the growth inhibitory effect of transforming growth factor-beta (TGF-beta) in many cell types. Mutational inactivation of Smads has been correlated with loss of responsiveness to TGF-beta-mediated signal transduction. In this study, we compare the contribution of ind...
The aberrantly high Smad3 phosphorylation levels and SBE activity in TGF-β-induced fibroblasts were dramatically decreased as a result of Shenks treatment. At the same time, Shenks was able to increase the expression of antioxidant-related genes, includingGclcandEc-sod, while reduce the ...
《TGFbeta信号非依赖Smad3核定位的机制与功能研究》是依托同济大学，由刘玲担任项目负责人的青年科学基金项目。中文摘要 TGFβ通路作为一条重要的信号转导途径在细胞增殖、分化及体内组织器官发育的过程中起关键作用。一般认为，TGFβ信号是通过其受体的丝-苏氨酸蛋白激酶活性，催化下游效应分子Smad2或Smad3磷酸化，磷酸...