We characterized the chemical composition of the Aβ peptides deposited in the brain parenchyma and cerebrovascular walls of triple transgenic Tg-SwDI mice that produce a rapid and profuse Aβ accumulation. The processing of the N- and C-terminal regions of mutant AβPP differs substantially ...
Over 650 proteins were quantified in vessel-enriched fractions from the brains of 3 and 9 month-old wild-type (WT) and Tg-SwDI mice. Sixty-five proteins were significantly increased in older WT animals and included several basement membrane proteins (nidogen-1, basement membrane-specific ...
B1R expression was found to be up-regulated in brains of Tg-SwDI mice, specifically in the vasculature, neurons, and astrocytes. Notably, administration of the B1R antagonist, R715, to 8-month-old Tg-SwDI mice for 8 weeks resulted in higher Aβ40 levels and increased thioflavin S–...
Increases in APOE levels are specific to 9 mos Tg-SwDI mice.James L. SearcyThierry Le BihanNatalia SalvadoresJames McCullochKaren Horsburgh
Effect of long‐term treatment with carbonic anhydrase inhibitors on the brain microcirculation in Tg‐SwDI micedoi:10.1002/alz.077325Gutiérrez‐Jiménez, EugenioRasmussen, Peter MondrupMikkelsen, Irene KlrkeKura, SreekanthFruekilde, Signe Kirk
Vasilevko, V., et al., Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice. J Neurosci, 2007. 27(49): p. 13376-83.Vitaly Vasilevko,Feng Xu,Mary Lou Previti, et al.Experimental Investigation of Antibody-Mediated Clearance ...
HTRA is located proximately to Aβ-laden vessels in the thalamus of 9 mos Tg-SwDI mice.James L. SearcyThierry Le BihanNatalia SalvadoresJames McCullochKaren Horsburgh
Scholtzova, H.; Do, E.; Dhakal, S.; Sun, Y.; Liu, S.; Mehta, P.D.; Wisniewski, T., Innate immunity stimulation via toll- like receptor 9 ameliorates vascular amyloid pathology in Tg-SwDI mice with associated cognitive benefits. The Journal of Neuroscience, 2017, 37, (4), 936-...
We observed that Tg-SwDI mice showed an initial upregulation of AChR gene expression early on (young adults and middle age adults), but a downregulation later on (old adults). Furthermore, transgenic animals displayed significant cell loss in the photoreceptor layer and inner retina of the ...
doi:10.1016/j.jalz.2006.05.2068David CribbsVitaly VasilevkoFeng XuMary Lou PrevitiWilliam E. Van NostrandElsevier Inc.Alzhmer's & Dementia:the Journal of the Alzhmer's Association