The utility of this tool will extend to the analysis of clusters of transcription factor binding sites in the wider area around each BLAST hit and implementation of other databases (e.g. microarray expression data), allowing for better prediction of real target genes....
Since TF-IDF does not detect LGT between sequences within a group, for the comparison we ignore such regions that are detected by ALFY; and if an atypical region is equally predicted in several sequences of potential donor groups, we treat this result as a single prediction for the ...
Toolbar Controls Overviews Date and Time Picker Controls Reference Queue Path Names Explorer Namespace Tree Control Date and Time Picker Controls Overview IAsyncOperation ComboBox MSMQDestination C++ COM Code Example: Opening a Queue IShellIconOverlayIdentifier INewShortcutHook IImageList Visual Ba...
& Adli, M. Cas9-chromatin binding information enables more accurate CRISPR off-target prediction. Nucleic Acids Res. 43, e118 (2015). Article PubMed PubMed Central Google Scholar Wu, X. et al. Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nat. Biotechnol. 32, ...
Linkage analysis was determined using the LDlink web tool v.5.1 (LDproxy, LDpair;https://ldlink.nci.nih.gov/). Candidate variants either achieved genome-wide significance in the first COVID-19 GWAS9or were in tight linkage (r2 > 0.8) with lead variants from the first two large CO...
Instead of relying entirely on computational prediction, we combined automated searches and manual curation to improve the quality of the database. In wDBTF, we define TFs as proteins that show sequence-specific DNA binding and are able to activate and/or repress transcription. The large genome ...
2.3. Analysis and Identification of B Cell Epitopes on TFPR1 The B cell epitopes on TFPR1 were predicted using IEDB online software (http://tools.iedb.org/ main/bcell/), and the structural and functional motifs of TFPR1 were analyzed by the tool "secondary structure consensus prediction" ...
This study aims to carry out the molecular docking, molecular dynamics studies, and prediction of ADMET properties of selected potential antiviral molecules. The study provides an insight into biomolecular interactions to understand the inhibitory mechanism and the spatial orientation of the tested ligands...
Prediction of Binding Affinities between the Human Amphiphysin-1 SH3 Domain and Its Peptide Ligands Using Homology Modeling, Molecular Dynamics and Molecul... The SH3 domain of the human protein amphiphysin-1, which plays important roles in clathrin-mediated endocytosis, actin function and signaling ...
Linkage analysis was determined using the LDlink web tool v.5.1 (LDproxy, LDpair;https://ldlink.nci.nih.gov/). Candidate variants either achieved genome-wide significance in the first COVID-19 GWAS9or were in tight linkage (r2 > 0.8) with lead variants from the first two large CO...