As a result, ASFV cannot utilize this pathway for cell entry, thereby exerting TET's inhibitory effect on ASFV (Fig. 8). Download: Download high-res image (715KB) Download: Download full-size image Fig. 8. Schematic diagram of TET inhibiting macropinocytosis of PAMs and ASFV entry. 3.12....
However, exclusive deletion of TET2 in murine models is not sufficient to result in T cell expansion, presumably due to redundant functions with other TET proteins. In addition, it has been demonstrated that TCR-mediated activation of T cells that lack Tet2 and have a point mutation of RhoAG...
Wu, X., Zhang, Y. TET-mediated active DNA demethylation: mechanism, function and beyond. Nat Rev Genet 18, 517–534 (2017). https://doi.org/10.1038/nrg.2017.33 Download citation Published30 May 2017 Issue DateSeptember 2017 DOIhttps://doi.org/10.1038/nrg.2017.33 Springer Nature LimitedAssoc...
et al. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Rep. 9, 1841–1855 (2014). Article CAS PubMed PubMed Central Google Scholar de la Rica, L. et al. PU.1 target genes undergo Tet2-coupled demethylation and ...
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Altogether, these data reinforce the demonstration that, in Sdhb−/− cells, DNA methylation of most PRC2 targets is the result of TET enzyme inhibition rather than increased PRC2 activity and recruitment of DNA methyltransferase. They are in accordance with other studies in ESCs showing that ...
to drive tumor immune evasion.100In addition, interestingly, FXR1, an m6A reader, guided TET1 to specific genomic loci near m6A RNA to result in DNA demethylation, revealing a novel regulation between RNA modification and DNA demethylation.101Similar models have been supported by many findings, whi...
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To further assess the inheritance of the demethylation pattern as a result of epimutagenesis, we selected T2 progeny of a late flowering ACT2:TET1-1.2-TET1individual containing and lacking the transgene. WGBS data from these two individuals was used to confirm the presence/absence of the sfGFP-...
In accordance with this result, co-immunoprecipitation analysis of GFP-tagged TET1, TET2, and TET3 expressed in HEK293T cells shows high enrichment of OGT in the pulldown (Fig. 2a). Download: Download high-res image (171KB) Download: Download full-size image FIGURE 2. TET proteins ...