manner13,14. However, exclusive deletion of TET2 in murine models is not sufficient to result in T cell expansion, presumably due to redundant functions with other TET proteins. In addition, it has been demonstrated that TCR-mediated activation of T cells that lack Tet2 and have a point mutat...
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However, exclusive deletion of TET2 in murine models is not sufficient to result in T cell expansion, presumably due to redundant functions with other TET proteins. In addition, it has been demonstrated that TCR-mediated activation of T cells that lack Tet2 and have a point mutation of RhoAG...
Protein interactions enable rapid regulation and represent an important regulation in TETs functions, which allow precise modifications in specific DNA loci timely.99For example, TET1 interacted with STAT1, contributed to the demethylation ofIRF1promoter and transcriptional upregulation of PD-L1, to drive...
The result reveals the slightly temperature dependent single exponential fluorescence lifetime of Coumarin 6. The temperature dependence of the viscosity could be fitted to the experimentally obtained change in the rotation correlation times. Even a precise calculation of the steady-state anisotropy values...
Altogether, these data reinforce the demonstration that, in Sdhb−/− cells, DNA methylation of most PRC2 targets is the result of TET enzyme inhibition rather than increased PRC2 activity and recruitment of DNA methyltransferase. They are in accordance with other studies in ESCs showing that ...
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To confirm the temperature shift result, we also dissected and stained TetAXXC brains with anti-Fas2 antibody at four time points between WPP and 48h APF. We first observed β axons crossing the midline in the TetAXXC brain 24h APF (Figure 2D). Thus, Tet is required during the first ...
et al. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Rep. 9, 1841–1855 (2014). Article CAS PubMed PubMed Central Google Scholar de la Rica, L. et al. PU.1 target genes undergo Tet2-coupled demethylation and ...
unevenly sized blastomeres might result from a slight acceleration of the cell cycle in someTetTKO cells or embryos, resulting in premature blastomere division and hence increased blastomere numbers. Indeed, the failure of triple TET-deficient embryos to develop beyond gastrulation49,50may at least ...