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Our unbiased transcriptomic analysis revealed 3560 differentially expressed genes (DEGs), among which 1478 were downregulated and 2,082 were upregulated (Fig.1dand Supplementary Fig.3). Given the established role of TET proteins as DNA demethylases the increased number of upregulated genes may appear...
essential to its biological function through biochemical and structural analysis.57In contrast, 5hmC regulated by TET2 is mainly located in gene bodies and exons rather than gene promoters.61Of note, TET1/3 can be also recruited by their binding proteins for context-specific DNA regions.62,63For...
essential to its biological function through biochemical and structural analysis.57In contrast, 5hmC regulated by TET2 is mainly located in gene bodies and exons rather than gene promoters.61Of note, TET1/3 can be also recruited by their binding proteins for context-specific DNA regions.62,63For...
The result showed that in the TetAXXC brains, 1,503 genes are up-regulated and 29 genes down-regulated compared to wild type (Figure 3A, Tables S4 and S5). Most of the up-regulated genes are expressed at low levels and GO term analysis showed that these genes functioned in sperm ...
Analysis of DNA Hydroxymethylation in SDHB-Deficient Tumors and Cells Previous studies suggested that DNA hypermethylation could result from succinate-driven inhibition of TET demethylases. To directly test this hypothesis, we precisely quantified 5mC and 5hmC modifications along the genome after enrichment...
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// physical simulations (finite element analysis). // // // // TetGen computes (weighted) Delaunay triangulations for three-dimensional // // (weighted) point sets, and constrained Delaunay triangulations for // // three-dimensional polyhedral domains. In the latter case, input edges /...
(DKO). This difference was obvious in principal component analysis (PCA) of the RNA-seq data: the biological replicates of WT cells, whether Treg or CD4+Foxp3–cells, clustered closely together, while those from Treg and CD4+Foxp3–cells obtained from the two 14-weeks-oldTet2/3fl/flFoxp...
The evolutionary rate and phylogenetic age distribution analysis of network member genes also support these network-based analyses. The present study provides an integrated view of TET gene family properties and might be informative for elucidating the molecular mechanisms of their biological functions....