Over the past decade, various types of cancer therapy (such as surgery, chemotherapy, radiotherapy, bone marrow transplantation, hormone therapy, targeted drug therapy and cryoablation treatment) have been applied to treat cancer, albeit these therapies are often associated with different side effects ...
E. RicciE. BourrelieX. MartinC. DumontetP. ClezardinG. ThalmannM. ColombelElsevier BVRicci E, Bourrelie E, Martin X et al. Testing and prognostic implications of prostate cancer stem cells in bone marrow [abstract 838]. Eur Urol Suppl 2011;10(2):265....
In one case study that came to Dr. Raca's lab, a patient first presented with what appeared to be solid tumors with no involvement of bone marrow so cytogenetic testing was not indicated. Without cytogenetic testing, it can take a long time to recognize a hematologi...
For cancer patients on chemotherapy, the "cure" can be as deadly as the disease itself. Adverse drug reactions are one of the leading causes of death among patients receiving cancer treatment. Ad Jackson Laboratory Professor Gary Churchill wants to change that. With a new two-year, $1 million...
cancer cells in these samples is representative of the distribution of cancer cells throughout the body. Bone marrow is often the default sample for MRD-testing in haematological cancers although a blood sample is a similarly or even more accurate relapse predictor in some settings [53,54,69,...
The Dutch-Belgian Hemato-Oncology Cooperative Group and Swiss Group for Clinical Cancer Research studied 1511 AML patients to assess the impact of MRD on post-remission treatments, including allo HCT, chemotherapy, or autologous HCT [52]. They found that MRD+ patients who achieved CR1 had ...
By combining genomic testing and next generation sequencing technology, a new partnership aims to advance predictive tests for multiple myeloma (MM). Dr Siobhan Glavey, RSCI Multiple myeloma is a cancer of plasma cells in the bone marrow that normally produce antibodies to help fight infection. ...
Lung cancer has the head start, although the diagnosis of leukemia is done on bone marrow specimens and blood. We are now applying it to solid tumors, but it is different because that solid tumor does not exist in the bloodstream. Those are the challenges, but we will get better with ...
Bone-marrow derived dendritic cells (DC) or macrophages (MØ were obtained from femurs of 8–12 female mice and cultured at 2 × 106 cells/mL in six-well plates in Dulbecco´s Modified Eagle´s Medium (DMEM) supplemented with 20% fetal calf serum, 1 mM glutamine, 1 mM nonesse...
In essence, our field has been incorporating both individual gene and genomic alterations into an ever-broader classification scheme. This wider genetic aperture is important for both risk assessment and treatment strategies which may influence a course of ac...