Tsukada, NNinomiya, SAoyama, YInoue, Y
aA plot of kinvsalkyne concentrations.bA plot of kinvsallylic bromide concentrations.cA plot of kinvscatalyst concentrations.dA plot of kinvsPMHS concentrations. Full size image Based on the experimental studies and previously reported literatures35,42,46,57,58,59, a possible mechanism is shown in...
Substrate scope.aScope of alkynes.bScope of cesium oxalates.cScope of aryl halides. Reaction conditions: Ir-1(3 mol%), NiCl2•glyme (20 mol%), dtbbpy (20 mol%), alkyne (0.1 mmol), oxalate (1.5 equiv.), bromide (2.0 equiv.), DMSO [0.05 M], 90 W blue LED, 36...
A Co(III)-catalyzed, internal and terminal alkyne-compatible indole synthesis protocol is reported herein. The N-amino (hydrazine) group imparts distinct, diverse reactivity patterns for directed C-H functionalization/cyclization reactions. Notable synthetic features include regioselectivity for a meta-...
This removal of tubulin dimers from the internal lattice is distinct from the well-known activities of motors removing tubulin from microtubule ends30. Bending of microtubules by fluid flow can also cause dissociation of tubulin subunits from the lattice31. Thus, several lines of evidence suggest ...
3-diene. Our design also allowed chemoselective insertion of terminal over internal or gem-substituted allylic ether (Set 5). It was shown that those diallyl ether2cycloisomerizations40were not as competitive as our desired intermolecular skipped diene3formation. Heteroatom effect of2is important on3:...
A 100 mL Schlenk flask equipped with magnetic stir bar was loaded with the corresponding amine (0.5 mmol), the CuNPs/MK10 catalyst (30 mg, 3 mol%), and the alkyne (0.5 mmol) in 0.8 mL of solvent (a mixture or xylenes). Dodecane (50 μL) as internal standard for GC-MS was also...
Results Using enhanced green fluorescent protein (EGFP) with the internal stop codon N150amber as a modeUl,swineginenithiaallnycaetdtegmrepetnedfltuooirnecsocrepnotrpatreotPeeikn a(EnGd FHPe)kwwitihthtMheminPtyelrRnSa(lYs3t8o4pF)c,oadwonellN-k1n5o0wamn braetrioansaal mmuodtaenl,t wwe...