To the best of our knowledge, this example is the first of an organomagnesium-catalyzed isomerization of alkynes. Notably, the reactions proceeded through temporally separated autotandem catalysis, thus allowing the isolation of the allene or internal alkyne species in good yields. Mechanistic ...
网络末端炔烃;端式炔类 网络释义
The reactivity pattern of phenylacetylene, a terminal alkyne, is significantly different from that of internal alkynes, such as 2-butyne. Other reactions, in which multiple alkyne–alkyne, alkyne–carbonyl and alkyne–Cp∗H couplings occur, were observed with this alkyne [10], [12]. When pheny...
The terminal alkyne is a functionality widely used in organic synthesis, pharmaceutical science, material science and bioorthogonal chemistry. This functionality is also found in acetylenic natural products, but the underlying biosynthetic pathways for its formation are not well understood. Here we report...
(Fig.5a). This result demonstrated excessive alkyne might be a ligand to coordinate with cobalt catalyst leading to the reduction of the rate of reaction. Measurements of the initial rates (kin) of the reaction with different concentrations of allylic bromide and (L3-H)•CoBr complex showed ...
Alkyne synthesis through coupling of gem-diborylalkanes with carboxylic acid esters Article 23 February 2023 Bis-silylation of internal alkynes enabled by Ni(0) catalysis Article Open access 04 January 2021 Regioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes Art...
alkyne[3+2]cycloaddition,oftenreferredtoas“click”chemistry 5 .This reactionhasenabledselectiveimagingandstudyofazide-oralkyne-labeledglycans,proteins, nucleicacidsandlipids.Despitethesuccesswithmacromolecules,thelabelingofnatural productshasnotbeenadequatelyexplored.Itisoftenchallengingtoobtaintaggednatural products...
This azide is subsequently reacted with a fluorophore alkyne. With this stepwise approach, we are able to achieve site-specific, internal backbone-labeling of de novo synthesized RNA molecules. 展开 关键词: alpha A-crystallin Astrocytes Small heat shock protein Phosphorylation Neuroprotection ...
These results showcase how macrocyclic ligands can be used to interrogate the mechanism and tune the outcome of terminal alkyne coupling reactions, and are discussed with reference to catalytic reactions mediated by the acyclic homologue [Rh(CNC㎝e)(C2H4)][BArF4] and solvent effects.doi:10.1002/...
In particular, the terminal alkyne has found broad utility via the Cu(i)-catalysed azide-alkyne cycloaddition ‘click’ reaction18. Here we report the discovery and characterization of a unique pathway to produce a terminal alkyne-containing amino acid in the bacterium Streptomyces cattleya. We ...