depressive symptoms occurred periodically, and sometimes for several weeks or months, when an antidepressant had been added to the therapy (i.e., clomipramine, mianserin, paroxetine, venlafaxine). However, with higher dosages of antidepressants, the mental state revealed some features of mixed state...
First, what magnitude of weight gain is associated with longer-term antidepressant use in general clinical populations rather than clinical trial populations? Second, are there clinically significant differences between these interventions in terms of weight gain because most studies lack direct head-to-...
Similarly, studies in which antidepressant medication was prescribed at entry to the trial were no more effective (SMDantidepressants at entry, 0.21; SMDantidepressants not consistently prescribed, 0.30; meta-regression β, −0.09; 95% CI, −0.24 to 0.06; P = .23; I2 = 50.7%). The ...
Furthermore, subgenual ACC activity has been found to change under influence of fluoxetine use (Mayberg et al, 2000), an antidepressant that is used as a treatment for both PTSD and depression. These studies suggest that targeting sub- genual ACC function is an effective treatment element for...
Estimates were refined using data for consultations and antidepressant medication collected for 50 patients for the whole period from general practitioner records. Resource use was valued at 2013 prices, using relevant unit costs (appendix p 2)32, 33, 34 or inflated using the hospital and community...
Despite encouraging antidepressant effects of all targets, long-term outcome beyond 1 year has only been described Sustained efficacy of DBS for depression BH Bewernick et al 1976 recently in 14 patients stimulated at Cg25 with 45% response after 2 years, 60% response after 3 years, and 55%...
(or after two trials of antidepressant drugs) [20]. This suggests that symptoms enduring for 1 year or longer are both an indicator of future chronicity and a need for further intervention. For the purposes of this study, we use the term ‘long-term depression’ to define patients with ...
Low-dose doxepin is a tricyclic antidepressant with significant antihistamine effects. Low-dose doxepin does not affect GABA-A receptors or trigger associated complications such as abuse, tolerance, withdrawal, or complicated sleep behaviors (Asnis et al., 2015). The residual effect of low-dose ...
However, the mean (SD) percentage of weeks receiving a therapeutic level of antidepressant was not significantly different between the irritable group and the nonirritable group: 27.2% (33.0%) vs 32.3% (36.0%) (P = .24, determined by use of the Wilcoxon rank sum test). During the ...
Induction of CREB in the hippocampus by antidepressant treatments could contribute to their therapeutic efficacy. By contrast, activation of CREB in the nucleus accumbens and several other regions by drugs of abuse or stress mediates certain aspects of drug addiction, and depressive and anxiety-like ...