The β-lactamase, new designated TEM-E1, has a pI of approximately 5.4 and lies in between the iso-electric focused bands of the β-lactamases TEM-1 and TEM-7. The TEM-E1 β-lactamase has a similar molecular weight of 22 000 to the TEM-1 and it is also inhibited by clavulanic acid...
The X-ray structure of Escherichia coli TEM1 beta-lactamase has been refined to a crystallographic R-factor of 16.4% for 22,510 reflections between 5.0 and... C Jelsch,L Mourey,JM Masson,... 被引量: 202发表: 1993年 Amino acid sequence of heat-stable enterotoxin produced by Escherichia ...
To date, more than 300 clinically-relevant beta-lactamase variants have been reported, and this number continues to increase. With the aim of obtaining insights into the evolutionary potential of beta-lactamases, an artificially engineered, catalytically active chimera of the Class A TEM-1 and PSE...