为了进一步确认2(TED-347)抑制了我们在FP分析中观察到的TEAD4和Yap1肽之间的相互作用,我们应用了使用全长Yap1蛋白的生物层干涉术(BLI)。发现谷胱甘肽S-转移酶(GST)标记的Yap1与TEAD4蛋白之间的结合亲和力为116.5±5.9 nM(图4D),与FAM-YAP 60-99肽的亲和力相当。与肽FP分析一样,在使用BLI研究TEAD4与GST-Yap1...
YAP1TEAD1PGC1 alphaMitochondria contribute to key processes of cellular function, while mitochondrial dysfunction is implicated in metabolic disorders, neurodegenerative diseases, and cardiovascular diseases, in which angiogenesis - the formation of new blood capillaries - is dysregulated. The Hippo ...
The Hippo TEAD-transcriptional regulators YAP1 and TAZ are central for cell renewal and cancer growth; however, the specific downstream gene networks involved in their activity are not completely understood. Here we introduce TEADi, a genetically encoded inhibitor of the interaction of YAP1 and TAZ...
However, the role of YAP1-TEAD1-PGC1α signaling in mitochondrial structure, cellular metabolism, and angiogenesis in endothelial cells (ECs) remains unclear. We now find that knockdown of TEAD1 decreases the expression of PGC1α and suppresses mitochondrial biogenesis, glycolysis, and oxygen ...
18 reagents referenced in YAP/TEAD1 and β-catenin/LEF1 synergistically induce estrogen receptor α to promote osteogenic differentiation of bone marrow stromal cells.
目的探讨核因子κb激酶亚基ε的抑制剂(IKBKE)、Yes相关蛋白1(YAP1)和转录增强结构域转录因子2(TEAD2)在结直肠癌(CRC)组织中的表达及其临床意义。方法收集2016年1月至2017年12月在蚌埠医科大学第一附属医院手术切除的142例CRC组织及对应癌旁组织,采用免疫组化法检测标本中IKBKE、YAP1和TEAD2的表达情况。分析3种蛋...
CIL56(CIL-56, CA3, CA-3)是一种有效的选择性ferroptosis诱导剂,通过增加铁依赖性ROS诱导铁死亡。CIL56还能抑制YAP1/Tead转录活性,对YAP1高表达食管腺癌表现出抗癌活性。此外,CIL56可以通过脂质合成限速酶ACC1触发细胞死亡。 产品性质 英文别名(English Synonym) ...
YAP1/TEAD1 associate with active enhancers.Claudia, SteinAnaïs, Flore BardetGuglielmo, RomaSebastian, BerglingIeuan, ClayAlexandra, RuchtiClaudia, AgarinisTobias, SchmelzleTewis, BouwmeesterDirk, Schübeler
本研究的目的是分析牛IFNT蛋白不同亚型的结构差异以及进而导致的功能差异,并研究了TEAD家族及YAP1对IFNT基因表达的调控作用,为完全阐明妊娠识别机制提供理论依据. 本研究通过Prosite数据库比对牛IFNT1和IFNTc1蛋白氨基酸序列,进而研究其蛋白的结构差异,发现IFNTc1蛋白存在着一段酪蛋白激酶2(CK2)序列,而其同源基因IFNT1...
YAP1-TEAD1 signaling controls angiogenesis and mitochondrial biogenesis through PGC1alpha. Microvasc Res. 2018;119:73–83. Article PubMed PubMed Central CAS Google Scholar Nagaraj R, Gururaja-Rao S, Jones KT, Slattery M, Negre N, Braas D, et al. Control of mitochondrial structure and ...