Also important is a diverse lymphocyte repertoire, because MRL/lpr mice lacking terminal deoxynucleotidyl transferase, an enzyme that adds nucleotides to the V(D)J segments during recombination, have decreased glomerular disease ( 25 , 26 ... Jiang,Chuancang,Foley,... - 《Journal of Immunology》...
We hypothesized that the enzyme terminal deoxynucleotidyl transferase (TdT) might be an ideal target of immunotherapy in B-ALL and T-ALL, for several reasons. First, as the function of TdT is to add N-nucleotides to the V-D-J junctions during recombination of the TCR and B-cell receptor9...
matrix bound TdT being capable of discriminating unnatural rNTPs against the natural dNTP substrates, may be the functionally organized form of the enzyme and that free TdT having lost the capability to distinguish between dNTP and rNTP may be the nonfunctional form of the enzyme in the thymus ...
3 8. Maintain TdT enzyme at -20 °C. The TdT enzyme should not be held on ice. For best results, remove the vial of TdT from the -20 °C freezer, pipette the required amount and immediately return to the -20 °C freezer. Alternatively, the enzyme can be placed into a -20 °C ...
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The ontogeny of hemopoietic cells which contain the enzyme terminal deoxynucleotidyl transferase (TdT) was studied in rats and mice. During fetal life, TdT-positive cells were first detected in the thymus, where they appeared on or about... KE Gregoire,I Goldschneider,RW Barton,... - 《Journa...