TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell typesTAR DNA-binding protein-43 (TDP-43) is a 43-kDa nuclear protein involved in regulation of gene expression. Abnormally, phosphorylated, ubiquitinated, and aggregated TDP-43 constitute a principal component of ...
TDP-43 interacts with other heterogeneous nuclear ribonucleoproteins (hnRNPs), including hnRNP A2, via its C-terminus and several hnRNP family members are involved in the cellular stress response. This relationship led us to investigate the role of TDP-43 in cellular stress. Our results demonstrate...
We review the relationship of stress granules and TDP-43 pathological aggregation. We propose two possible models for TDP-43 aggregate formation. In one model, TDP-43 aggregation is "independent" of stress granule formation. In another model, stress granules are "precursors" to TDP-43 aggregation...
Although it mostly resides in the nucleus, TDP-43 also shuttles to the cytoplasm33 where it is involved in stress granule formation34,35,36,37,38,39,40, axonal transport of target mRNAs41,42, and mRNA translation36,43,44,45,46,47. TDP-43 interacts with several proteins that are ...
g, Stress-granule formation in multinucleated myotubes derived from C2C12 cells. Immunofluorescence using antibodies against stress-granule proteins, G3BP1 and PABP1, after NaAsO2 treatment or control conditions for 60 min. n = 3 independent experiments, each showing similar results. Zoom, ...
病理性TDP-43通过影响细胞内多种生理过程介导了神经退变的发生,如TDP-43可损害线粒体功能,引发内质网应激(endoplasmic reticulum stress,ER stress),TDP-43的病理性聚集与应激颗粒(stress granule,SG)有密切关系,TDP-43可与细胞内降解途径相互作用产生细胞保护或细胞毒性效应等。 关键词: 肌萎缩侧索硬化症;TDP-43...
Small molecules could therapeutically prevent cytoplasmic aggregations of TDP-43 by post-translational modifications through (i) protease kinase inhibitors and inhibiting TDP-43 hyperphosphorylation, (ii) inhibiting solid state stress granule formations, and (iii) regulating protein homeostasis pathways UPS, ...
A new insight into TDP-43 accumulation is developing through studies identifying TDP-43 association with RNA stress granule proteins [16, 17]. Stress granules (SGs) are cytoplasmic sites of stalled mRNA pre-initiation complexes induced by oxidative changes, heat shock or osmotic stress where the ...
TDP-43 serves a critical function in the cellular stress response. Notably, the TDP-43 protein can sense intracellular signals, such as misfolding proteins Sup35, Pab1, and Pub1 [116]. In ovariectomized mice, progesterone treatment can promote TDP-43 expression, suggesting that TDP-43 may be...
Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP. Molecular neurodegeneration 7, 54 (2012). Article PubMed PubMed Central CAS Google Scholar Parker, S. J. et al. Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates. Neurochem...