Three of these candidates, XPO7, XPO4, and DHX8, are export factors known to mediate the nuclear export of proteins and RNA.30,31,32 Using immunofluorescence, we assessed cytoplasmic and nuclear intensity of endogenous CHMP7 protein HeLa cells following the confirmation of protein depletion (...
These models, having demonstrated promise in predicting inhibitor candidates, can be further utilized to generate a comprehensive list of plausible inhibitors. Subsequent experimental validation will be crucial to confirm the efficacy of these candidates. Physical experimental techniques, such as enzyme ...