the phosphorylation of PLK1, TCTP, and Cdk1 within cells, while decreasing p53 levels. This mechanism was involved in cell cycle arrest, mitotic catastrophe, DNA damage repair blockade, and suppression of cell proliferation, consequently increasing the sensitivity of nasopharyngeal carcinoma to radiothera...
The C-terminal polo-box domain (PBD) of PLK1 is required for substrate recognition and subcellular localization of the enzyme24,28. TCTP contains not only PLK1-dependent phosphorylation sites (Ser46 and Ser64), but also a potential PBD-binding site (Thr65), which is a priming phosphorylation...
In addition, Plk1 was decreased by TCTP knockdown. Taken together, our results demonstrate that TCTP is a microtubule-associating protein required to regulate spindle microtubule dynamics during meiotic maturation in mouse oocytes.Hyuk-JoonJeonSeung...