PLK1 PathwayThe loss of PLK1 expression can induce pro-apoptotic pathways and inhibit growth.Search Main menu Skip to primary content Skip to secondary content Home AGK BGJ398 CID44216842 KWA 0711 PXD101 tetrathiomolybdateDamage Incident throughout Modern along with Hip-Hop Ballerinas: A deliberate ...
Molecularly, by directly binding the promoter, KLF14 functions as a transcriptional activator of PLK1, a polo-like kinase whose overexpression induced excessive reactive oxygen species (ROS) production. Transient knockdown of PLK1 was sufficient to suppress KLF14 overexpression-potentiated endothelial ...
2015. Inhibition of Plk1 represses androgen signaling pathway in castration-resistant prostate cancer. Cell Cycle 14:2142-2148. http://dx.doi.org/10.1080/15384101 .2015.1041689.Zhang Zhe, Chen Long, Wang Hexiang, et al. Inhibition of PLK1 represses androgen signaling pathway in castration-resistant...
Knocking down the expression of PLK1 in pancreatic cancer cells can inhibit the effect of insulin on the biological behavior of pancreatic cancer. In addition, we found that insulin activates the PI3K/AKT pathway in pancreatic cancer cells, and that inhibition of this pathway suppresses PLK1 ...
Blocking the PLK1-dependant phosphorylation of FOXO1 restored the pro-apoptotic function of FOXO1 in PCa. Combining PLK1 inhibition with nocodazole (to induce mitotic arrest) had synergistic antitumor effects in vitro, with minimal effect on normal prostate epithelial cells. These findings shed light ...
Molecularly, by directly binding the promoter, KLF14 functions as a transcriptional activator of PLK1, a polo-like kinase whose overexpression induced excessive reactive oxygen species (ROS) production. Transient knockdown of PLK1 was sufficient to suppress KLF14 overexpression-potentiated endothelial ...
PLK1ProliferationTaken together, circRNA_102541 was upregulated in atherosclerosis, and knockdown of circRNA_102541 suppressed cell proliferation while promotedapoptosis of HUVEC cells via miR-296-5p/PLK1. This novel pathway may serve essential roles on the development of atherosclerosis, andcircRNA_102541...
Tanshinone IIA suppresses the progression of lung adenocarcinoma through regulating CCNA2-CDK2 complex and AURKA/PLK1 pathwayZiheng LiYing ZhangYuan ZhouShunbo Zhang
2015. Identification of AREG and PLK1 pathway modulation as a potential key of the response of intracranial 9L tumor to microbeam radiation therapy. Int J Cancer 136:2705-2716.Bouchet A, Sakakini N, El Atifi M, Le Clec'h C, Bra€uer-Krisch E, Rogalev L, et al. Identification of ...
Furthermore, we found that the Wnt/β‐catenin signalling pathway may be essential for PLK1‐mediated HSCs activation. Together, blocking PLK1 effectively suppressed liver fibrosis by inhibiting HSC activation, which may provide a new treatment strategy for liver fibrosis.doi:10.1111/jcmm.15356...