PLK1 PathwayThe loss of PLK1 expression can induce pro-apoptotic pathways and inhibit growth.Search Main menu Skip to primary content Skip to secondary content Home AGK BGJ398 CID44216842 KWA 0711 PXD101 tetrathiomolybdateDamage Incident throughout Modern along with Hip-Hop Ballerinas: A deliberate ...
Molecularly, by directly binding the promoter, KLF14 functions as a transcriptional activator of PLK1, a polo-like kinase whose overexpression induced excessive reactive oxygen species (ROS) production. Transient knockdown of PLK1 was sufficient to suppress KLF14 overexpression-potentiated endothelial ...
2015. Inhibition of Plk1 represses androgen signaling pathway in castration-resistant prostate cancer. Cell Cycle 14:2142-2148. http://dx.doi.org/10.1080/15384101 .2015.1041689.Zhang Zhe, Chen Long, Wang Hexiang, et al. Inhibition of PLK1 represses androgen signaling pathway in castration-resistant...
Knocking down the expression of PLK1 in pancreatic cancer cells can inhibit the effect of insulin on the biological behavior of pancreatic cancer. In addition, we found that insulin activates the PI3K/AKT pathway in pancreatic cancer cells, and that inhibition of this pathway suppresses PLK1 ...
Molecularly, by directly binding the promoter, KLF14 functions as a transcriptional activator of PLK1, a polo-like kinase whose overexpression induced excessive reactive oxygen species (ROS) production. Transient knockdown of PLK1 was sufficient to suppress KLF14 overexpression-potentiated endothelial ...
Blocking the PLK1-dependant phosphorylation of FOXO1 restored the pro-apoptotic function of FOXO1 in PCa. Combining PLK1 inhibition with nocodazole (to induce mitotic arrest) had synergistic antitumor effects in vitro, with minimal effect on normal prostate epithelial cells. These findings shed light ...
Cell cycle arrestALDOAATMPLK1Pancreatic cancerALDOA is a glycolytic enzyme found mainly in developing embryos, adult muscle and various malignant tumours, including pancreatic tumours. Our previous study revealed that ALDOA, an oncogene, can promote the proliferation and metastasis of pancreatic tumours. ...
In summary, TSA could suppress the progression of LUAD by inducing cell apoptosis and arresting cell cycle, and these were done by regulating CCNA2-CDK2 complex and AURKA/PLK1 pathway. These findings are the first to demonstrate the molecular mechanism of TSA in treatment of LUAD combination ...
(2015). Inhibition of Plk1 re- presses androgen signaling pathway in castration-resistant prostate cancer. Cell Cycle 14, 2142-2148.Zhang Z, Chen L, Wang H, et al. Inhibition of PLK1 represses an⁃ drogen signaling pathway in castration- resistant prostate cancer [J]. Cell Cycle, 2015,...
Tanshinone IIA suppresses the progression of lung adenocarcinoma through regulating CCNA2-CDK2 complex and AURKA/PLK1 pathwayZiheng LiYing ZhangYuan ZhouShunbo Zhang