TCF1 also has the potential to become an important clinical biomarker for assessing the prognosis of tumour immunotherapy and the success of viral control in treating HIV and hepatitis C virus infection. Here, we summarize the key findings on TCF1 across the fields of T cell immunity and ...
TCF1还有可能成为重要的临床生物标志物，用于评估肿瘤免疫治疗的预后以及治疗HIV和丙型肝炎病毒感染的病毒控制是否成功。2021年6月14日，美国哈肯萨克大学薛海晖团队（中国医科大学为第一单位，赵旭东为第一作者）在（IF=40.36）在线发表题为“TCF1 in T cell immunity: a broadened frontier”的综述文章，该综述总结...
TCF1 in T cell immunity: a broadened frontier 2022, Nature Reviews Immunology Tissue regulatory T cells: regulatory chameleons 2021, Nature Reviews Immunology Bacteria-Based Cancer Immunotherapy 2021, Advanced Science T cell factor 1: A master regulator of the T cell response in disease 2020, Scien...
TCF1还有可能成为重要的临床生物标志物,用于评估肿瘤免疫治疗的预后以及治疗HIV和丙型肝炎病毒感染的病毒控制是否成功。 2021年6月14日,美国哈肯萨克大学薛海晖团队(中国医科大学为第一单位,赵旭东为第一作者)在Nature Reviews Immunology(IF=40.36)在线发表题为“TCF1 in T cell immunity: a broadened frontier”的综...
The T cell-specific DNA-binding protein TCF-1 is a central regulator of T cell development and function along multiple stages and lineages. Because it interacts with β-catenin, TCF-1 has been classically viewed as a downstream effector of canonical Wnt
2021年6月14日,美国哈肯萨克大学薛海晖团队(中国医科大学为第一单位,赵旭东为第一作者)在Nature Reviews Immunology(IF=40.36)在线发表题为“TCF1 in T cell immunity: a broadened frontier”的综述文章,该综述总结了TCF1 在 T 细胞免疫领域的主要发现,并反思了探索 TCF1 及其下游转录程序作为改善抗病毒和抗肿瘤...
2021年6月14日,美国哈肯萨克大学薛海晖团队(中国医科大学为第一单位,赵旭东为第一作者)在Nature Reviews Immunology (IF=40.36)在线发表题为“TCF1 in T cell immunity: a broadened frontier”的综述文章,该综述总结了 TCF1 在 T 细胞免疫领域的主要发现,并反思了探索 TCF1 及其下游转录程序作为改善抗病毒和抗肿...
Xue TCF1 in T cell immunity: a broadened frontier Nat. Rev. Immunol., 22 (2022), pp. 147-157, 10.1038/s41577-021-00563-6 Google Scholar 58 F.C. Steinke, S. Yu, X. Zhou, B. He, W. Yang, B. Zhou, H. Kawamoto, J. Zhu, K. Tan, H.-H. Xue TCF-1 and LEF-1 act ...
CD8+ T cell homeostasis is maintained by the cytokines IL-7 and IL-15. Here we show that transcription factors Tcf1 and Lef1 were intrinsically required for homeostatic proliferation of CD8+ T cells. Multiomics analyses showed that Tcf1 recruited the gen
The mechanisms underlying the heightened protection mediated by central memory CD8+ T (TCM) cells remain unclear. Here we show that the transcription factor Tcf1 was required in resting TCM cells to generate secondary effector CD8+ T cells and to clear p