Full size image Cellular O-GlcNAcylation is highly dynamic in response to various environmental stimuli26. Thus, we investigated whether PGK1 glycosylation was also dynamically regulated when subjected to different metabolic stresses. Elevation of cellular levels of reactive oxygen species (ROS) by H2O2...
In a functional TCA cycle (Figure 2, reactions 1 to 13), the presence of this anaplerotic pathway depends on two enzymes: isocitrate lyase, ICL (EC: 4.1.3.1), and malate synthase (EC: 2.3.3.9) (Figure 2, reactions 14 and 15). The full glyoxylate cycle is a combination of glyoxylate...
Full information on reaction schemes, atom transition specifications, and fluxes can be found in Supplemental File S1. 2.2. Inhibitor Effects on Endothelial Cell Glucose Metabolism We then examined the metabolite inputs (glucose, glutamine) and outputs (lactate, glutamine) for endothelial cells that...