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Experiments were conducted with a drug efflux-deficient (ED) strain of S. cerevisiae to improve the dynamic range of the growth assays (Stepanov et al., 2008). We first assessed the effects of lowered TCA metabolite abundance by deleting mpc1, a subunit of the mitochondrial pyruvate carrier ...
Conclusion The effect produced by the theaflavin on various parameters was comparable to that of metformin鈥攁 reference antidiabetic drug. These findings suggest that theaflavin can replace the commercial drugs which could lead to reduction in toxicity and side effect caused by the later as well as...
Drug tolerance is an acute defence response preceding a fully drug-resistant state and tumour relapse; however, there are few therapeutic agents targeting drug tolerance in the clinic. Here we show that miR-147b initiates a reversible state of tolerance to the epidermal growth factor receptor (EGF...
‘real’ effect of the drug then it should have also been detected in our chemical analyses performed after 10 min of stimulation. That is, if cycloserine compromised aerobic energy delivery during the early phase of contraction, then phosphocreatine degradation should have been greater at the end...
Considering the evolution of drug resistance, effective multitarget antibacterial agents are necessary to control infectiousness and treat pathogen infections. Itaconic acid (IA) is a eukaryotic immune cell metabolite synthesized by cis-aconitic acid decarboxylase in the tricarboxylic acid (TCA) cycle, ...