examined. Despite Hsp90 inhibitors' presence in clinical trials, substantial adverse effects and the emergence of drug resistance pose significant obstacles. Therefore, potent Hsp70 and Hsp40 inhibitors might provide a valuable solution to the limitations of Hsp90 inhibitors and other approved anticancer...
Major constraints associated with recombinant AAV (rAAV) vectors are: their limited packaging size (up to 5 Kb), the high number of genome copies required for transduction and the possible presence of pre-existing immunity against the vector capsid, thus complicating vector administration15,16. ...
Chronic exposure to Pb has been associated with adverse effects in humans causing diseases such as anemia, headaches, convulsions, muscle weakness, ataxia, tremors, and paralysis [15]. Pb and Al are neurotoxic agents, which may be bioaccumulated in the body, causing serious damage in the ...