细胞受感染后细胞内产生cGAMP,cGAMP结合激酶STING,STING再激活下游激酶TBK1,TBK1磷酸化转录因子IFR-3,促使其入核,转录干扰素IFNβ。STING-TBK1-IRF-3这条路径是已知的,该研究论文在此基础上进行细节探讨。 一 Fig. 1 | The nine C-terminal residues of STING are crucial for STINGmediated signalling and binding...
目的:探索干扰素TLR3-TBK1-IRF-3信号通路在EV71手足口病脑炎中枢神经系统损伤中的作用机制.方法选取2014年1月至2015年1月手足口病患儿144例(观察组)及健康体检儿童36例(对照组),通过脑脊液检查及临床诊断,分成5组,正常儿童体检组,普通手足口病儿童2d组(A组),普通手足口病儿童5d组(B组),手足口病脑炎2d组(C组...
SIKEisanIKKe/TBK1-associatedsuppressor ofTLR3-andvirus-triggeredIRF-3activation pathways JunHuang 1,4 ,TingLiu 1,4 ,Liang-GuoXu 2 , DanyingChen 1 ,ZhongheZhai 1 andHong-BingShu 1,3, * 1 CollegeofLifeSciences,PekingUniversity,Beijing,China,...
International Journal of Molecular Sciences Article Thymoquinone Suppresses IRF-3-Mediated Expression of Type I Interferons via Suppression of TBK1 Nur Aziz 1 ID , Young-Jin Son 2,* and Jae Youl Cho 1,* ID 1 Department of Integrative Biotechnology and Biomedical Institute for Convergence (BICS),...
Involvement of the IKK-Related Kinases TBK-1/IKKi and Cullin-based Ubiquitin Ligases in IRF-3 degradationdoi:10.4049/jimmunol.177.8.5059Bibeau-Poirier, A.Gravel, S.-P.Clement, J.-F.Rolland, S.Rodier, G.Coulombe, P.Hiscott, J.
SIKE is an IKKε/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activa- tion pathways. EMBO J. 24: 4018-4028.Huang J, Liu T, Xu LG, Chen D, Zhai Z, Shu HB. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. ...
Reduction of ubiquitinated forms of RIG-I, STING, TBK1 and IRF-3 in the presence of NL63 PLP2-TM.Li SunYaling XingXiaojuan ChenYang ZhengYudong YangDaniel B. NicholsMark A. ClementzBridget S. BanachKui LiSusan C. Baker
Objective: In the research conducted during the ongoing pandemic period, it has been determined that IRF7, TBK1, IFNAR1, IFNAR2, and TLR3 immunity genes play an important role in the predisposition to SARS-CoV-2 infection. However, there is no information about ...
细胞受感染后细胞内产生cGAMP,cGAMP结合激酶STING,STING再激活下游激酶TBK1,TBK1磷酸化转录因子IFR-3,促使其入核,转录干扰素IFNβ。STING-TBK1-IRF-3这条路径是已知的,该研究论文在此基础上进行细节探讨。 一 Fig. 1 | The nine C-terminal residues of STING are crucial for STINGmediated signalling and binding...