We assessed the expression of T-bet along with PD-1, IFN-γ and perforin, in HBV-specific CD8+ T cells from resolved acute hepatitis B (rAHB) patients, chronic hepatitis B (CHB) patients, as well as asymptomatic HBV carriers (ASCs). We observed dynamic changes of T-bet, PD-1, IFN...
T-bet expression by both T-cells and DC is critically important for B7-DC XAb-induced downregulation of IL4, upregulation of interferon-γ and suppression of allergic airway inflammation. Moreover, retroviral reconstitution of T-bet expression in T-bet KO DC rescued their ability to modulate ...
导读 T-bet (T-box expressed in T cell) 是2000年哈佛大学Glimcher研究小组分离出的T-box家族的新型转录因子, 因最初发现其T盒 (T box) 仅表达T细胞而得名。T-bet基因位于人的17号染色体上, 与鼠类的T-bet存在88%的同源性。T-bet含有530个氨基酸, 其中有189个氨基酸是T-box结合结构域 (T box DNA-bi...
The expression of T-bet mRNA in the spleen was evaluated 0, 8, 16, 24, 48, and 96 h after LPS injection using real-time PCR. Immunohistochemistry was performed on the iris whole-mounts as well as on frozen sections of the spleen to evaluate T-bet protein expression. Terminal ...
These results thus suggest that the use of T-bet expression as a biomarker of the potential immunologic effects of anthracyclines might not be appropriate. In addition, since taxanes are always associated with trastuzumab, we could not determine if the immune response induced by taxanes plus ...
we demonstrate that T-bet expression by either TFH or GC B cells independently drives antibody isotype class switching. Specifically, T cell-specific loss of T-bet promotes IgG1, whereas B cell-specific loss of T-bet inhibits IgG2a/c switching. Combined, this work highlights that the context-...
3. Lu Y, Bocca S, Anderson S, et al. Modulation of the expression of the transcription factors T-bet and GATA-3 in immortalized human endometrial stromal cells (HESCs) by sex steroid hormones and cAMP [J].Reproductive sciences...
Objective To investigate the expression of T-bet on human lymphocytes inhibited by siRNA. Methods Four different siRNAs (siRNA-1, siRNA-2, siRNA-3, and siRNA-co) were designed and synthysized and transfected into freshly isolated human lymphocytes with cationic liposome. The changes of T-bet ...
We found that T-bet expression during T cell activation was strongly dependent on IFN-gamma signaling and STAT1 activation, but was independent of STAT4. Ectopic T-bet expression strongly increased IFN-gamma production in T(H)2 cells activated by PMA-ionomycin, but weakly increased IFN-gamma ...
结果寻常性银屑病患者皮损中CI)4和T.bet的表达明显高于正常人皮肤(P<0.01),且CD4 表达较强的皮损中T.bet的表达也较强,但两者表达阳性的淋巴细胞分布并不一致;而银屑病患者皮损中CI)8和GA7rA-3 的表达与正常人皮肤差异无显著性。结论寻常性银屑病皮损的形成和发展可能通过T-bet调控。 [关键词】银屑病;T-...