(2009). T-bet expression is regulated by EGR1-mediated signaling in activated T cells. Clin Immunol 131, 385-394.Shin HJ,Lee JB,Park SHet al.T-bet expression is regulated by EGR1-mediated signaling in activated T cells. Clinical Immunology . 2009...
导读 T-bet (T-box expressed in T cell) 是2000年哈佛大学Glimcher研究小组分离出的T-box家族的新型转录因子, 因最初发现其T盒 (T box) 仅表达T细胞而得名。T-bet基因位于人的17号染色体上, 与鼠类的T-bet存在88%的同源性。T-bet含有530个氨基酸, 其中有189个氨基酸是T-box结合结构域 (T box DNA-bi...
T-bet expression in HBV-specific CD8+ T cells. a Percentage of T-bet + cells in the total CD8+ T cell population (CD8 + T-bet+/CD8+) determined by flow cytometry. Data are shown as median (IQR). IQR = interquartile range. P > 0.05, by Kruskal-Wallis H test....
导读 T-bet (T-box expressed in T cell) 是2000年哈佛大学Glimcher研究小组分离出的T-box家族的新型转录因子, 因最初发现其T盒 (T box) 仅表达T细胞而得名。T-bet基因位于人的17号染色体上, 与鼠类的T-bet存在88%的同源性。T...
CONCLUSIONS: The results show that T-bet expression in both the iris and the spleen, and in apoptotic cells in the iris parallel the severity of intraocular inflammation after systemic LPS administration. These results suggest that T-bet may play a significant role in the dynamics of EIU. 展开...
(TFH) cells express the prototypical T helper 1 tranion factor T-bet. Several studies have demonstrated essential but conflicting roles for T-bet in TFH biology. Understanding the basis of this controversy is crucial, as modulation of T-bet expression instructs TFH differentiation and ultimately ...
3. Lu Y, Bocca S, Anderson S, et al. Modulation of the expression of the transcription factors T-bet and GATA-3 in immortalized human endometrial stromal cells (HESCs) by sex steroid hormones and cAMP [J].Reproductive sciences...
These results thus suggest that the use of T-bet expression as a biomarker of the potential immunologic effects of anthracyclines might not be appropriate. In addition, since taxanes are always associated with trastuzumab, we could not determine if the immune response induced by taxanes plus ...
结果寻常性银屑病患者皮损中CI)4和T.bet的表达明显高于正常人皮肤(P<0.01),且CD4 表达较强的皮损中T.bet的表达也较强,但两者表达阳性的淋巴细胞分布并不一致;而银屑病患者皮损中CI)8和GA7rA-3 的表达与正常人皮肤差异无显著性。结论寻常性银屑病皮损的形成和发展可能通过T-bet调控。 [关键词】银屑病;T-...
We found that T-bet expression during T cell activation was strongly dependent on IFN-gamma signaling and STAT1 activation, but was independent of STAT4. Ectopic T-bet expression strongly increased IFN-gamma production in T(H)2 cells activated by PMA-ionomycin, but weakly increased IFN-gamma ...