Mechanism of action and uses The drugs used clinically are produced fromtaxane, a diterpenoid extracted from the bark of the Pacific yew tree (Taxus brevifolia). Taxanes promote the assembly of microtubules but inhibit their depolymerisation, leading to the formation of stable and nonfunctional micro...
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Mechanism of action of taxol. Trends Pharmacol Sci 1992; 13: 134–136. 21 Wahl AF, Donaldson KL, Fairchild C, Lee FY, Foster SA, Demers GW et al. Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis. Nat Med 1996; 2: 72–79. 22 Patel...
Taxol, an antineoplastic agent with a novel mechanism of action, is currently undergoing Phase I trials at The Johns Hopkins Hospital, Baltimore. The autho... - 《Cancer》 被引量: 487发表: 1989年 General motors cancer research foundation prizes Charles F. Kettering prize. Determining the effica...
In the field of antineoplastic chemotherapy, taxanes (paclitaxel and docetaxel) represent an important class of compounds, with broad activity in solid tumours (Rowinsky, 1997). Taxanes are tubulin-binding agents, characterised by a unique mechanism of action, that is, microtubule stabilisation (Horwi...
of 2–10mg/mL, compared with 0.3–1.2mg/mL for paclitaxel. It undergoes biphasic elimination (two-compartment model of disposition) with a terminal half-life of 27h (5.8h for paclitaxel). The clearance is 43% slower (15L/h/m2) and the mean volume of distribution is 632L/m2, ...
It is usually combined with carboplatin to treat many types of cancer6. PTX's success in cancer therapy is due to its broad spectrum of antitumor activity in addition to its unique mechanism of action. PTX is a microtubule-stabilizing agent that selectively binds to microtubules and disrupts ...
Gemcitabine was well tolerated in previously pretreated metastatic breast cancer. In view of its toxicity profile, and its novel mechanism of action, gemcitabine warrants further evaluation in breast cancer patients, both as a single agent and in combination treatment schedules. 展开 关键词: Metastatic...
Azarenko O, Smiyun G, Mah J, Wilson L, Jordan MA (2014) Antiproliferative mechanism of action of the novel taxane cabazitaxel as compared with the parent compound docetaxel in MCF7 breast cancer cells. Mol Cancer Ther 13(8): 2092–2103. Corbett TH, White K, Polin L, Kushner J, ...
taxane derivative or analog. It is generally believed that the mechanism of action of taxanes involves promoting formation and hyperstabilization of microtubules, thus blocking cell division. As used herein, the term “taxane” refers to a taxanes, taxines, and taxoids, as well as derivatives or...