Tau13 Antibody Preferentially Immunoprecipitates High Molecular Weight Tau ProteinsAggregationAlzheimer's diseasetautauopathyThe accumulation of tau protein aggregates is a pathological hallmark in Alzheimer's disease (AD) and other neurodegenerative diseases. However, the identity of the toxic tau ...
2, Walker, L.C., Diamond, M.I., Duff, K.E., and Hyman, B.T. (2013).Mechanisms of protein seeding in neurodegenerative diseases.JAMA Neurol. 70,304–310. 3, Takeda, S., Wegmann, S., Cho, H., DeVos, S.L., Commins, C., Roe, A.D.,Nicholls, S.B., Carlson, G.A., Pi...
Molecular Weight: 48.3 kDa Form: freeze-dried powder Storage: -80°C (as supplied) Stability: ≥6 months Purity: ≥80% estimated by SDS-PAGE Supplied in: 1×PBS (pH 7.2) Background Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21....
Horse 产品类型 一抗 研究领域 细胞生物 神经生物学 信号转导 激酶和磷酸酶 细胞骨架 Alzheimer's 蛋白分子量 predicted molecular weight: 143kDa 性 状 Lyophilized or Liquid 免 疫 原 KLH conjugated synthetic peptide derived from human TTBK1/BDTK 亚 型 IgG 纯化方法 affinity purified by Protein A 储...
Using a lentiviral-mediated rat model of hippocampal NFD, we demonstrated that wild-type human Tau protein is axonally transferred from ventral hippocampus neurons to connected secondary neurons even at distant brain areas such as olfactory and limbic systems indicating a trans-synaptic protein transfer...
Proteins were normalized to Ponceau stain values obtained from a region at a similar molecular weight as each protein of interest. Alzheimer’s Disease Neuroimaging Initiative (ADNI) phenotype and biomarker determination Inclusion and exclusion criteria, clinical and neuroimaging protocols, and other ...
Tau and the key proteins required to produce Aβ [APP, BACE1, and components of γ-secretase (presenilin-1)] are expressed in a variety of tissues throughout the body (as reported by The Human Protein Atlas [262] (Fig.3)). Whilst tau is predominantly found in brain and peripheral nerve...
The pathological features of AD are neurofibrillary tangles (NFTs) composed of highly phosphorylated tau and senile plaques (SPs) composed of amyloid β protein (Aβ). It was suggested that Cu2 + induced hyperphosphorylation of tau and Zn2 + deposits on SPs. Clioquinol (CQ) has a mild ...
MN1020 detects PHF-tau (Ser202/Thr205)a which has a predicted molecular weight of approximately 79 kDa. This product is a Low Endotoxin formulation. Purity is >95% as determined by SDS-PAGE. 靶标信息 Tau is a neuronal microtubule-associated protein found predominantly on axons. The ...
Takeda, S. et al. Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain.Nat. Commun.6, 8490 (2015). ArticleCASPubMedGoogle Scholar Shipton, O. A. et al. Tau protein is required for amyloid β-induced impairment of hippocam...