doi:10.1016/j.str.2019.09.003Konstantin I. PopovKarl A.T. MakepeaceEvgeniy V. PetrotchenkoNikolay V. DokholyanChristoph H. BorchersCell Press
Geometry based prediction of tau protein sites and motifs associated with misfolding and aggregation Masumi Sugiyama Kenneth S. Kosik Eleni Panagiotou ResearchOpen Access25 Mar 2025 Scientific Reports Volume: 15, P: 10283 AFsample2 predicts multiple conformations and ensembles with AlphaFold2 AF...
Tau is a microtubule-associated protein involved in regulation of assembly and spatial organization of microtubule in neurons. However, in pathological conditions, tau monomers assemble into amyloid filaments characterized by the cross-β structures in a number of neurodegenerative diseases known as tauopat...
Predicting the functional sites of a protein from its structure, such as the binding sites of small molecules, other proteins or antibodies, sheds light on its function in vivo. Currently, two classes of methods prevail: machine learning models built on top of handcrafted features and comparative...
Machine learning methods hold the promise to reduce the costs and the failure rates of conventional drug discovery pipelines. This issue is especially pressing for neurodegenerative diseases, where the development of disease-modifying drugs has been part
Tau protein (Tau) tauopathy neurodegenerative disease phosphotyrosine aggregation microtubule post-translational modification (PTM) phosphorylation amyloid lipid binding Introduction The misfolding and aggregation of the microtubule (MT)-associated protein Tau have been linked to the pathogenesis of several neur...
Using GraphPAC, we are able to detect novel clusters in proteins that are known to exhibit mutation clustering as well as identify clusters in proteins without evidence of prior clustering based on current methods. Specifically, by utilizing the spatial information available in the Protein Data Bank...
2018, 19, 856 2 of 24 locatIentd. J.iMnolt.hScei. 2E0R18,m19,exmFObRraPnEEeRaRcEtVinIEgWas a calcium-sensing protein, whereas Orai1 is loca2teofd24in the plasmalemma forming the calcium-selective pore of the CRAC channel [5]. STIM and Orai are exprtersasnesd-mienmablrlantiesspuro...
Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central to the aetiology of Parkinson’s disease, a considerable amount of work has gone into uncovering its basic cellular function. This effort has led to the impli
Retrospective summary of research milestones Due to their large size, cylindrical nuclear pore complex penetrating the nuclear envelope were discovered under electron microscopy as early as 1959 (Fig.1).10,11. The first nuclear localization signal, which localizes yeast ribosomal protein L3 to the nu...