It is possible that the findings in acute hippocampal slices could involve tau-dependent alterations in circuit development or compensation. To account for this possibil- ity, we used dissociated hippocampal neuronal cultures to test whether loss of tau can reverse the synaptic changes observed in ...
Secondly, tau may also play a role in cell signalling. The longest brain tau isoform with 441 amino acids (aa) has 85 putative sites of phosphorylation. Thus, tau may act as a buffer for cell signalling. For instance, tau may serve as a ‘phosphorylation sink’ for the p25-Cdk5 complex...
作者: A Ghirelli,N Tosakulwong,SD Weigand,HM Clark,F Ali,H Botha,JR Duffy,RL Utianski,M Buciuc,ME Murray 展开 摘要: Objective To examine associations between tau and amyloid‐beta (Aβ) molecular PET and both Alzheimer‐related pathology and 4‐repeat tau pathology in autopsyヽonfirmed ...
Neurofilament Light (NfL) is a biomarker for early neurodegeneration in Alzheimer’s disease (AD). This study aims to examine the association between plasma NfL and multi-modal neuroimaging features across the AD spectrum and whether NfL predicts future
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Multiple cell types can have immune functions in the brain, for example microglia, astrocytes, perivascular macrophages, meningeal macrophages, choroid plexus macrophages, and infiltrating peripheral myeloid cell types [304]. However, microglia are of particular interest as they are the principal macrophag...
Therefore, we performed 24 h electroencephalography (EEG) recording using electrodes placed during the MCAO procedure to determine alterations in neuronal circuit response. In both tau+/+ and tau−/− mice, baseline EEG recordings were comparable; as was the drop in EEG activity within 1 h ...
connections affects selective functional brain circuitries, thereby determining the behavioral dysfunction depending on the site of initiation of Tau-pathology. “Early” pathological forms of Tau rather than fully mature NFTs as causal culprits for neuronal dysfunction ...