In this paper we use the operational Tau and Adomian meth- ods with Pade approximants for solving the general Non-linear Volterra Integro- Differential Equations (NVIDE). We will present our method based on the matrix form of (NVIDE). The corresponding unknown coefficients of our method have...
A Wnt1 regulated Frizzled-1/β-catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: therapeutical relevance for neuron survival and neuroprotection. Mol Neurodegen 2011; 13: 6–49. 40. Valencia A, Reeves PB, Sapp E, Li X, ...
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Thus, such a feedback circuit may be an important pathway to rejuvenate the macroautophagy pathway, which is known to wane with aging [59]. Conclusions Atg7 cKO in mouse forebrain neurons led to an age- dependent neurodegeneration with ubiquitin/p62-posi- tive and phospho-tau/GSK3β ...
(TBST) alleviated behavioral and cognitive deficits in transgenic tau or Aβ mouse models18,19, spurring significant interest in using HDAC6 inhibitors as AD therapies. However, we previously showed that acetylated tau is a substrate for HDAC6 and that inhibition of HDAC6 could result in ...
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sometimes even for millimeters: they were thinner than dendrites and usually less intensely stained (Supplementary fig. 3, online resource). Interestingly, ‘duos’ or ‘triplets’ of close ‘hugging’ TH+somas were frequently noticed in the LC core, as revealed by horizontal optical slicing with...
Multiple cell types can have immune functions in the brain, for example microglia, astrocytes, perivascular macrophages, meningeal macrophages, choroid plexus macrophages, and infiltrating peripheral myeloid cell types [304]. However, microglia are of particular interest as they are the principal macrophag...