These results suggest that the TATA site in the transcription elongation complex in vivo is occupied with transcription factor TBP/TFIID. When considered in light of previous work, these findings support a model in which transcription activation involves reinitiation from a promoter that contains both...
which could lead to enhanced pharmacological activities of BBR based on its inhibitory effect on the transcription of TATA box-dependent genes. As for GC box-dependent genes, because BBR cannot reach an effective dosage to influence the transcription of these genes in living cells, the interaction...
An in vitro transcription system from mammary was established to study transcription of the long terminal repeat (LTR) of the (). Experiments with progressive 5'-deletion constructs of the LTR revealed that a 19-base pair (bp) region from -41 to -23 bp, encompassing the box and flanking ...
For eukaryotic genes that use the TATA box, alterations in the position or composition of this promoter element can have significant effects on gene expression. If we were to change one base in the TATA box sequence, transcription of the corresponding exon(s) would go down; this should be in...
Emerging evidence suggests that components of the small RNAs pathway interact with chromatin to regulate nuclear events, such as gene transcription. However, it has recently been reported that in some cases, gene transcription regulation by cellular miRNAs can occur via targeting the TATA-box motif ...
A TATA box is a consensus sequence in the promoter region of many eucaryotic genes that binds a general transcription factor and hence specifies the position where transcription is initiated by the RNA polymerase. Rights and permissions Reprints and permissions ...
别名: TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa; TAF15; TAF2J; TAFII 20/TAFII 15; TAFII20; TAFII20/TAFII15; Transcription initiation factor TFIID 20/15 kDa subunits; Transcription initiation factor TFIID subunit 12; TAF12_HUMAN. 抗体来源:Rabbit/Mo...
In Drosophila , some core promoters have both TATA box and DPE or only one of the two (Kutach AK, Kadonaga JT 2000 Mol Cell Biol 20:4754). Pribnow box , Hogness (Goldberg) box , transcription factors , transcription complex , open promoter complex , asparagine synthetase , core promoter...
transcription initiation site (Struhl K 1989 Annu Rev Biochem 58:1051). Many housekeeping genes and the RAS oncogene do not have this sequence (Suzuki Y et al 2001 Genome Res 11:677). In case of the absence of TATA, some other A and T nucleotides may associate with the TATA-box-...
We have previously reported that the 5'-flanking sequence upstream from the "TATA" box modulates the faithful transcription initiation of the fibroin gene in a homologous whole cell extract prepared from the silk glands, whereas such a modulating effect is not observed in a HeLa cell extract. Su...